Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Nolatrexed. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Nolatrexed SCHEMBL29420099 | 1.00 | TYMS (0.97) | TYMSDHFR | |
| Nolatrexed SCHEMBL316632 | 1.00 | TYMS (0.97) | TYMSDHFR | |
| Nolatrexed SCHEMBL710461 | 0.99 | TYMS (1.00) | TYMSDHFR | |
| SCHEMBL7826662 | 0.86 | TYMS (1.00) | TYMS | |
| Nolatrexed SCHEMBL18489 | 0.79 | TYMS (0.66) | TYMSDHFR | |
| Nolatrexed SCHEMBL1649851 | 0.78 | TYMS (0.65) | TYMSDHFR | |
| SCHEMBL16807869 | 0.75 | TYMS (0.61) | TYMSDHFR | |
| SCHEMBL7827130 | 0.73 | TYMS (1.00) | TYMSDHFR | |
| SCHEMBL7831197 | 0.72 | TYMS (1.00) | TYMSDHFR | |
| SCHEMBL27555186 | 0.71 | TYMS (0.58) | TYMS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105535991-A | Amphiphilic basic group conjugate nanometer particles for treating tumors and preparation method thereof | UNIV SHANGHAI JIAOTONG | 2016-05-04 | — | — | CN | claimed |
| CN-112703004-B | Methods and compositions for cancer treatment using recombinant dendritic cells | 雷诺瓦罗生物制药公司 | 2025-02-14 | — | — | CN | disclosed |
| CN-112703004-A | Methods and compositions for cancer treatment using recombinant dendritic cells | 伊诺奇安生物制药公司 | 2021-04-23 | — | — | CN | disclosed |
| CN-105092752-B | A kind of with liquid chromatography separation nolatrexed dihydrochloride and the method about material | 北京康辰药业股份有限公司 | 2017-03-01 | — | — | CN | disclosed |
| CN-103298818-B | Spiro-oxindole MDM2 antagonist | 密歇根大学董事会 | 2016-06-29 | — | — | CN | disclosed |
| CN-105535991-A | Amphiphilic basic group conjugate nanometer particles for treating tumors and preparation method thereof | UNIV SHANGHAI JIAOTONG | 2016-05-04 | — | — | CN | disclosed |
| CN-104619352-A | Compositions containing hc-ha/ptx3 complexes and methods of use thereof | TISSUETECH INC | 2015-05-13 | — | — | CN | disclosed |
| CN-103282025-A | Melt-extruded solid dispersions containing apoptosis-inducing agents | ABBVIE INC | 2013-09-04 | — | — | CN | disclosed |