Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 15/20 | 0.45 |
| ▸ | PKM | P14618 | 5/20 | 0.45 |
| ▸ | POLB | P06746 | 3/20 | 0.45 |
| ▸ | GAA | P10253 | 6/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | HTT | P42858 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.40 |
| ▸ | LMNA | P02545 | 4/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.38 |
| ▸ | XBP1 | P17861 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1700546 | 0.90 | MAPT (0.52) | MAPTPKMPOLBGAANPSR1 | |
| SCHEMBL29017803 | 0.84 | MAPT (0.53) | MAPTPKMPOLBGAANPSR1 | |
| SCHEMBL30451856 | 0.84 | MAPT (0.53) | MAPTPKMPOLBGAANPSR1 | |
| Tert-Butyl Formate SCHEMBL27916741 | 0.81 | MAPT (0.46) | MAPTPKMPOLBGAANPSR1 | |
| Tert-Butyl Formate SCHEMBL28092200 | 0.81 | MAPT (0.46) | MAPTPKMPOLBGAANPSR1 | |
| Tert-Butyl Formate SCHEMBL27935376 | 0.79 | MAPT (0.48) | MAPTPKMPOLBGAANPSR1 | |
| Tert-Butyl Formate SCHEMBL27916739 | 0.78 | MAPT (0.47) | MAPTPKMPOLBGAANPSR1 | |
| SCHEMBL1541487 | 0.78 | MAPT (0.64) | MAPTPKMPOLBGAANPSR1 | |
| Hydrochloric Acid SCHEMBL28666327 | 0.77 | MAPT (0.54) | MAPTPKMPOLBGAANPSR1 | |
| Tert-Butyl Formate SCHEMBL27916828 | 0.75 | MAPT (0.43) | MAPTPKMPOLBGAANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109966294-A | Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases | 艾伯维爱尔兰无限公司 | 2019-07-05 | — | — | CN | disclosed |
| CN-109897038-A | Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases | 艾伯维爱尔兰无限公司 | 2019-06-18 | — | — | CN | disclosed |
| CN-103282025-A | Melt-extruded solid dispersions containing apoptosis-inducing agents | ABBVIE INC | 2013-09-04 | — | — | CN | disclosed |