Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 7/20 | 0.36 |
| ▸ | MTOR | P42345 | 3/20 | 0.35 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.35 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.35 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.35 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.35 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.35 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.35 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.35 |
| ▸ | AURKA | O14965 | 1/20 | 0.35 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.35 |
| ▸ | RPS6KA4 | O75676 | 1/20 | 0.35 |
| ▸ | KIT | P10721 | 1/20 | 0.35 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.35 |
| ▸ | CDK2 | P24941 | 1/20 | 0.35 |
| ▸ | FLT3 | P36888 | 1/20 | 0.35 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.35 |
| ▸ | RPS6KA2 | Q15349 | 1/20 | 0.35 |
| ▸ | RPS6KA1 | Q15418 | 1/20 | 0.35 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1921960 | 0.90 | PIK3CA (0.36) | PIK3CAMTORPIK3CDPIK3CBPIK3CG | |
| SCHEMBL27950026 | 0.89 | NTRK1 (0.36) | PIK3CAMTORPIK3CDPIK3CBPIK3CG | |
| SCHEMBL27935555 | 0.88 | DGAT2 (0.37) | PIK3CAMTORPIK3CDPIK3CBPIK3CG | |
| SCHEMBL27935551 | 0.86 | KCNH2 (0.39) | PIK3CAMTORPIK3CDPIK3CBPIK3CG | |
| SCHEMBL27935532 | 0.86 | SCN9A (0.38) | CHEK1AURKARPS6KA5RPS6KA4KIT | |
| SCHEMBL27950065 | 0.86 | PIK3CA (0.37) | PIK3CAMTORPIK3CDPIK3CBPIK3CG | |
| SCHEMBL27935526 | 0.85 | PIK3CA (0.35) | PIK3CAMTORPIK3CDPIK3CBPIK3CG | |
| SCHEMBL27935539 | 0.83 | PIK3CA (0.35) | PIK3CAMTORPIK3CDPIK3CBPIK3CG | |
| SCHEMBL27935509 | 0.83 | DGAT2 (0.38) | SCN9AJAK2JAK3 | |
| SCHEMBL27935556 | 0.82 | SCN9A (0.38) | CHEK1AURKARPS6KA5RPS6KA4KIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102203067-B | Hedgehog pathway modulators | IRM LLC | 2014-01-15 | — | — | CN | claimed |
| CN-102203067-B | Hedgehog pathway modulators | IRM LLC | 2014-01-15 | — | — | CN | disclosed |