Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPBAR1 | Q8TDU6 | 7/20 | 0.62 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 3/20 | 0.53 |
| ▸ | MAPT | P10636 | 3/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | GAA | P10253 | 2/20 | 0.50 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3826089 | 0.89 | GPBAR1 (0.60) | GPBAR1EPAS1HSD17B10LMNAMAPT | |
| SCHEMBL2470614 | 0.89 | GPBAR1 (0.60) | GPBAR1EPAS1HSD17B10LMNAMAPT | |
| SCHEMBL30395326 | 0.89 | GPBAR1 (0.60) | GPBAR1EPAS1HSD17B10LMNAMAPT | |
| SCHEMBL3822684 | 0.88 | HSD17B10 (0.70) | GPBAR1EPAS1HSD17B10LMNAMAPT | |
| SCHEMBL11408570 | 0.85 | EPAS1 (0.61) | GPBAR1EPAS1HSD17B10LMNAMAPT | |
| SCHEMBL5773636 | 0.85 | GPBAR1 (0.57) | GPBAR1EPAS1HSD17B10LMNAMAPT | |
| SCHEMBL2473847 | 0.84 | GPBAR1 (0.56) | GPBAR1EPAS1HSD17B10LMNAMAPT | |
| SCHEMBL2924198 | 0.83 | GPBAR1 (0.58) | GPBAR1EPAS1LMNAMAPTALDH1A1 | |
| SCHEMBL27927955 | 0.83 | HSD17B10 (0.55) | GPBAR1EPAS1HSD17B10LMNAMAPT | |
| SCHEMBL3976223 | 0.82 | HTT (0.50) | GPBAR1EPAS1HSD17B10LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103313982-A | Phenyl-isoxazole derivatives and process for the preparation thereof | IL YANG PHARM CO LTD | 2013-09-18 | — | — | CN | claimed |
| CN-103313982-A | Phenyl-isoxazole derivatives and process for the preparation thereof | IL YANG PHARM CO LTD | 2013-09-18 | — | — | CN | disclosed |