Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPBAR1 | Q8TDU6 | 5/20 | 0.60 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30395326 | 1.00 | GPBAR1 (0.60) | GPBAR1EPAS1HSD17B10MEN1KMT2A | |
| SCHEMBL27936741 | 0.89 | GPBAR1 (0.62) | GPBAR1EPAS1HSD17B10MEN1KMT2A | |
| SCHEMBL6695996 | 0.88 | GPBAR1 (0.49) | GPBAR1EPAS1HSD17B10MEN1KMT2A | |
| SCHEMBL12544125 | 0.88 | GPBAR1 (0.49) | GPBAR1EPAS1HSD17B10MEN1KMT2A | |
| SCHEMBL2470614 | 0.88 | GPBAR1 (0.60) | GPBAR1EPAS1HSD17B10MEN1KMT2A | |
| SCHEMBL3822684 | 0.87 | HSD17B10 (0.70) | GPBAR1EPAS1HSD17B10MEN1KMT2A | |
| SCHEMBL12457425 | 0.84 | GPBAR1 (0.59) | GPBAR1HSD17B10MEN1KMT2ALMNA | |
| SCHEMBL5774873 | 0.84 | LMNA (0.54) | GPBAR1MEN1KMT2ALMNAALDH1A1 | |
| SCHEMBL5773636 | 0.84 | GPBAR1 (0.57) | GPBAR1EPAS1HSD17B10MEN1KMT2A | |
| SCHEMBL11408570 | 0.84 | EPAS1 (0.61) | GPBAR1EPAS1HSD17B10MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 30 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116236478-A | Application of aromatic heterocyclic formamide compound | 浙江大学 | 2023-06-09 | — | — | CN | disclosed |
| EP-2699566-B1 | PHENYL-ISOXAZOL DERIVATIVES AND PREPARATION PROCESS THEREOF | IL-YANG PHARM CO LTD (KR) | 2017-02-22 | — | — | EP | disclosed |
| CN-103313982-B | Phenyl-isoxazole derivatives and process for the preparation thereof | IL-YANG PHARM. CO.,LTD. (KR) | 2016-02-03 | — | — | CN | disclosed |
| US-9132126-B2 | Phenyl-isoxazole derivatives and preparation process thereof | IL-YANG PHARM. CO., LTD. (KR) | 2015-09-15 | — | — | US | disclosed |
| EP-2767536-B1 | Isoxazolo-pyridine derivatives | HOFFMANN LA ROCHE (CH) | 2015-09-02 | — | — | EP | disclosed |
| EP-2227467-B1 | ISOXAZOLO-PYRIDINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2014-12-31 | — | — | EP | disclosed |
| EP-2767536-A1 | ISOXAZOLO-PYRIDINE DERIVATIVES | F. Hoffmann-La Roche AG (CH) | 2014-08-20 | — | — | EP | disclosed |
| EP-2699566-A1 | PHENYL-ISOXAZOL DERIVATIVES AND PREPARATION PROCESS THEREOF | Il-Yang Pharm. Co., Ltd. (KR) | 2014-02-26 | — | — | EP | disclosed |
| US-20140031364-A1 | PHENYL-ISOXAZOL DERIVATIVES AND PREPARATION PROCESS THEREOF | IL-YANG PHARM. CO., LTD. (KR) | 2014-01-30 | — | — | US | disclosed |
| CN-103313982-A | Phenyl-isoxazole derivatives and process for the preparation thereof | IL YANG PHARM CO LTD | 2013-09-18 | — | — | CN | disclosed |
| US-20040006226-A1 | Isoxazole pyrazoloindane derivatives as cognition enhancing GABA-A alpha 5 subtype ligands | MERCK SHARP & DOHME LTD. (GB) | 2004-01-08 | — | — | US | disclosed |
| US-6670373-B1 | Inhibiting resistant neoplasms where the resistance is conferred by multidrug resistance protein; N-3,4,5-trimethoxyphenyl-3-(3-azidomethyl-isoxazolo(4,5-c) -1,2-dihydro-6-chloro-quinolin-2-on-1-yl)phenylacetamide | ELI LILLY AND COMPANY | 2003-12-30 | — | — | US | disclosed |
| EP-1226131-B1 | ISOXAZOLECARBOXAMIDE DERIVATIVES | RECORDATI CHEM PHARM (IT) | 2003-12-17 | — | — | EP | disclosed |
| CN-1379767-A | Isoxazole carboxamide derivatives | RECORDATI CHEM PHARM (CH) | 2002-11-13 | — | — | CN | disclosed |
| US-20020161012-A1 | Isoxazolecarboxamide derivatives | RECORDATI, S.A., CHEMICAL AND PHARMACEUTICAL COMPANY | 2002-10-31 | — | — | US | disclosed |
| EP-1226131-A2 | ISOXAZOLECARBOXAMIDE DERIVATIVES | RECORDATI INDUSTRIA CHIMICA E FARMACEUTICA S.p.a. (IT) | 2002-07-31 | — | — | EP | disclosed |
| EP-1224189-A2 | CONDENSED DIHYDROQUINOLINONE DERIVATIVES FOR INHIBITING MRP1 | ELI LILLY AND COMPANY (US) | 2002-07-24 | — | — | EP | disclosed |
| US-6365591-B1 | FOR THERAPY OF OBSTRUCTIVE SYNDROMES OF THE LOWER URINARY TRACT, INCLUDING BENIGN PROSTATIC HYPERPLASIA (BPH), AND IN THE TREATMENT OF LOWER URINARY TRACT SYMPTOMS (LUTS) AND NEUROGENIC LOWER URINARY TRACT DYSFUNCTION (NLUTD) | RECORDATI, S.A., CHEMICAL AND PHARMACUETICALS COMPANY (CH) | 2002-04-02 | — | — | US | disclosed |
| WO-2001029015-A2 | ISOXAZOLECARBOXAMIDE DERIVATIVES AS ALPHA1-ADRENERGIC RECEPTOR ANTAGONISTS | RECORDATI INDUSTRIA CHIMICA E FARMACEUTICA S.P.A. (IT) | 2001-04-26 | — | — | WO | disclosed |
| WO-2001027116-A2 | CONDENSED DIHYDROQUINOLINONE DERIVATIVES FOR INHIBITING MRP1 | ELI LILLY AND COMPANY (US) | 2001-04-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020161012-A1 | Isoxazolecarboxamide derivatives | ADRA1D, NMUR1, NMUR2 | GPBAR1 703/4885EPAS1 1684/4885HSD17B10 2181/4885 |
| US-20040006226-A1 | Isoxazole pyrazoloindane derivatives as cognition enhancing GABA-A alpha 5 subtype ligands | GABRA5, GABRB1, GABRA4 | GPBAR1 354/4885EPAS1 1874/4885HSD17B10 1916/4885 |
| US-20140031364-A1 | PHENYL-ISOXAZOL DERIVATIVES AND PREPARATION PROCESS THEREOF | PIR, ALPL, PIGS | GPBAR1 4105/4885EPAS1 926/4885HSD17B10 3731/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.