Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 6/20 | 0.64 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.41 |
| ▸ | CDK4 | P11802 | 2/20 | 0.41 |
| ▸ | CCND1 | P24385 | 2/20 | 0.41 |
| ▸ | CDK9 | P50750 | 2/20 | 0.41 |
| ▸ | CDK6 | Q00534 | 2/20 | 0.41 |
| ▸ | CDK11A | Q9UQ88 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | IKBKB | O14920 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | PTGER4 | P35408 | 2/20 | 0.35 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | CHUK | O15111 | 1/20 | 0.34 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20559620 | 0.90 | PDE5A (0.76) | PDE5ACCNT1CDK4CCND1CDK9 | |
| SCHEMBL27950966 | 0.89 | PDE5A (0.69) | PDE5ACCNT1CDK4CCND1CDK9 | |
| SCHEMBL291116 | 0.89 | PDE5A (0.83) | PDE5AALDH1A1HPGDMAPTLMNA | |
| SCHEMBL29832187 | 0.89 | PDE5A (0.83) | PDE5AALDH1A1HPGDMAPTLMNA | |
| SCHEMBL291123 | 0.83 | PDE5A (0.68) | PDE5ACCNT1CDK4CCND1CDK9 | |
| SCHEMBL290592 | 0.83 | PDE5A (0.66) | PDE5ACCNT1CDK4CCND1CDK9 | |
| SCHEMBL26647638 | 0.82 | PDE5A (0.57) | PDE5ACCNT1CDK4CCND1CDK9 | |
| SCHEMBL27950945 | 0.81 | PDE5A (0.57) | PDE5ACCNT1CDK4CCND1CDK9 | |
| SCHEMBL27937575 | 0.79 | PDE5A (0.60) | PDE5ACCNT1CDK4CCND1CDK9 | |
| SCHEMBL27950937 | 0.79 | PDE5A (0.60) | PDE5ACCNT1CDK4CCND1CDK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103547267-A | Treatment of addiction and impulse control disorders using PDE7 inhibitors | OMEROS CORP | 2014-01-29 | — | — | CN | disclosed |