Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 6/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | AURKA | O14965 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | CCNT1 | O60563 | 4/20 | 0.43 |
| ▸ | CDK4 | P11802 | 4/20 | 0.43 |
| ▸ | CCND1 | P24385 | 4/20 | 0.43 |
| ▸ | CDK9 | P50750 | 4/20 | 0.43 |
| ▸ | CDK6 | Q00534 | 4/20 | 0.43 |
| ▸ | CDK11A | Q9UQ88 | 4/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.40 |
| ▸ | SIK1 | P57059 | 1/20 | 0.40 |
| ▸ | SIK2 | Q9H0K1 | 1/20 | 0.40 |
| ▸ | SIK3 | Q9Y2K2 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27937598 | 0.94 | PDE5A (0.52) | PDE5AALDH1A1HPGDAURKATSHR | |
| SCHEMBL27950966 | 0.93 | PDE5A (0.69) | PDE5AALDH1A1HPGDAURKATSHR | |
| SCHEMBL27950945 | 0.92 | PDE5A (0.57) | PDE5AALDH1A1HPGDAURKATSHR | |
| SCHEMBL27950943 | 0.92 | PDE5A (0.50) | PDE5AALDH1A1HPGDAURKATSHR | |
| SCHEMBL299899 | 0.88 | PDE5A (0.47) | PDE5AALDH1A1HPGDAURKATSHR | |
| SCHEMBL290899 | 0.87 | PDE5A (0.53) | PDE5AALDH1A1HPGDAURKATSHR | |
| SCHEMBL28020392 | 0.87 | AURKA (0.48) | PDE5AALDH1A1HPGDAURKA | |
| SCHEMBL291478 | 0.87 | PDE5A (0.50) | PDE5AALDH1A1HPGDCCNT1CDK4 | |
| SCHEMBL290609 | 0.87 | PDE5A (0.52) | PDE5AALDH1A1HPGDAURKATSHR | |
| SCHEMBL20559620 | 0.86 | PDE5A (0.76) | PDE5AALDH1A1HPGDTSHRCCNT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4275752-A2 | TREATMENT OF ADDICTION AND IMPULSE-CONTROL DISORDERS USING PDE7 INHIBITORS | Omeros Corporation (US) | 2023-11-15 | — | — | EP | disclosed |