Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.60 |
| ▸ | NPC1 | O15118 | 3/20 | 0.60 |
| ▸ | RAB9A | P51151 | 3/20 | 0.60 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.59 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.56 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.56 |
| ▸ | CCNK | O75909 | 1/20 | 0.55 |
| ▸ | CDK12 | Q9NYV4 | 1/20 | 0.55 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.53 |
| ▸ | KDR | P35968 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | NR1I3 | Q14994 | 1/20 | 0.49 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.49 |
| ▸ | SNCA | P37840 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2190292 | 0.86 | CYP19A1 (0.66) | MEN1KMT2ANPC1RAB9ACYP19A1 | |
| SCHEMBL28330051 | 0.82 | MEN1 (0.77) | MEN1KMT2ANPC1RAB9ACYP19A1 | |
| SCHEMBL23291452 | 0.80 | L3MBTL1 (0.49) | MEN1KMT2ANPC1RAB9ACYP19A1 | |
| SCHEMBL31211590 | 0.80 | L3MBTL1 (0.49) | MEN1KMT2ANPC1RAB9ACYP19A1 | |
| SCHEMBL1805271 | 0.80 | CCNK (0.56) | MEN1KMT2ANPC1RAB9ACYP19A1 | |
| SCHEMBL2506847 | 0.79 | MEN1 (0.57) | MEN1KMT2ANPC1RAB9ACYP19A1 | |
| SCHEMBL17084397 | 0.79 | MEN1 (0.77) | MEN1KMT2ANPC1RAB9ACYP19A1 | |
| SCHEMBL19026569 | 0.78 | MEN1 (0.71) | MEN1KMT2ANPC1RAB9ACYP19A1 | |
| SCHEMBL2192371 | 0.78 | FLT3 (0.72) | PTGS2KDR | |
| SCHEMBL16620124 | 0.77 | HSP90AB1 (0.61) | MEN1KMT2ANPC1RAB9ACYP19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103619170-B | Spleen tyrosine kinase (SYK) inhibitor containing amino-pyridine | 默沙东公司 | 2016-07-06 | — | — | CN | disclosed |
| CN-103619170-A | Amino-pyridine-containing spleen tyrosine kinase (SYK) inhibitors | MERCK SHARP & DOHME | 2014-03-05 | — | — | CN | disclosed |