Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR5A | P47898 | 3/20 | 0.41 |
| ▸ | S1PR1 | P21453 | 8/20 | 0.38 |
| ▸ | S1PR3 | Q99500 | 8/20 | 0.38 |
| ▸ | S1PR2 | O95136 | 6/20 | 0.38 |
| ▸ | LPAR2 | Q9HBW0 | 3/20 | 0.38 |
| ▸ | S1PR4 | O95977 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | COMT | P21964 | 1/20 | 0.36 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.35 |
| ▸ | GLO1 | Q04760 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27939768 | 1.00 | HTR5A (0.41) | HTR5AS1PR1S1PR3S1PR2LPAR2 | |
| SCHEMBL13276262 | 0.92 | HTR5A (0.38) | HTR5AS1PR1S1PR3S1PR2LPAR2 | |
| SCHEMBL13276070 | 0.91 | HTR5A (0.43) | HTR5AS1PR1S1PR3S1PR2LPAR2 | |
| SCHEMBL17060893 | 0.89 | HTR5A (0.40) | HTR5AS1PR1S1PR3S1PR2LPAR2 | |
| SCHEMBL13276274 | 0.86 | S1PR1 (0.50) | HTR5AS1PR1S1PR3S1PR2LPAR2 | |
| SCHEMBL13279803 | 0.86 | S1PR1 (0.43) | S1PR1S1PR3S1PR2LPAR2S1PR4 | |
| SCHEMBL13276325 | 0.85 | S1PR3 (0.60) | S1PR1S1PR3S1PR2LPAR2S1PR4 | |
| SCHEMBL13276059 | 0.85 | S1PR3 (0.60) | S1PR1S1PR3S1PR2LPAR2S1PR4 | |
| SCHEMBL13276261 | 0.83 | S1PR1 (0.44) | S1PR1S1PR3S1PR2LPAR2S1PR4 | |
| SCHEMBL13464647 | 0.82 | S1PR1 (0.39) | HTR5AS1PR1S1PR3S1PR2LPAR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103619828-A | Phenyl bicyclic methyl amine derivatives as sphingosine-1 phosphate receptors modulators | ALLERGAN INC | 2014-03-05 | — | — | CN | claimed |
| CN-103619828-A | Phenyl bicyclic methyl amine derivatives as sphingosine-1 phosphate receptors modulators | ALLERGAN INC | 2014-03-05 | — | — | CN | disclosed |