Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | MME | P08473 | 1/20 | 0.40 |
| ▸ | ACE | P12821 | 1/20 | 0.40 |
| ▸ | CPA1 | P15085 | 1/20 | 0.40 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.40 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.40 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27996080 | 0.93 | LMNA (0.40) | LMNATAAR1TSHRMAPK1HIF1A | |
| SCHEMBL4568795 | 0.88 | TSHR (0.44) | TAAR1TSHRMAPK1HIF1AADRB2 | |
| SCHEMBL4568810 | 0.88 | TSHR (0.44) | TAAR1TSHRMAPK1HIF1AADRB2 | |
| SCHEMBL4568962 | 0.88 | TSHR (0.44) | TAAR1TSHRMAPK1HIF1AADRB2 | |
| SCHEMBL17031423 | 0.86 | TAAR1 (0.45) | TAAR1MMEACECPA1ACE2 | |
| SCHEMBL11993594 | 0.86 | TAAR1 (0.45) | TAAR1MMEACECPA1ACE2 | |
| SCHEMBL2207529 | 0.84 | KMT2A (0.42) | TAAR1TSHRMAPK1HIF1AKDM4E | |
| SCHEMBL29818631 | 0.84 | KMT2A (0.42) | TAAR1TSHRMAPK1HIF1AKDM4E | |
| SCHEMBL2206745 | 0.84 | HIF1A (0.44) | TAAR1TSHRMAPK1HIF1AADRB2 | |
| SCHEMBL2206737 | 0.84 | HIF1A (0.44) | TAAR1TSHRMAPK1HIF1AADRB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103553945-A | Alkoxy compounds for disease treatment | ACUCELA INC | 2014-02-05 | — | — | CN | disclosed |
| CN-101889017-B | Alkoxy compounds for the treatment of diseases | ACUCELA INC | 2013-11-27 | — | — | CN | disclosed |