Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GUCY1A1 | Q02108 | 1/20 | 0.42 |
| ▸ | GUCY1B1 | Q02153 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | CASP1 | P29466 | 1/20 | 0.38 |
| ▸ | CASP7 | P55210 | 1/20 | 0.38 |
| ▸ | CFD | P00746 | 2/20 | 0.38 |
| ▸ | BAZ2B | Q9UIF8 | 5/20 | 0.37 |
| ▸ | BAZ2A | Q9UIF9 | 5/20 | 0.37 |
| ▸ | BRD4 | O60885 | 2/20 | 0.37 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.37 |
| ▸ | BRD2 | P25440 | 1/20 | 0.37 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18549701 | 0.80 | KDM4E (0.46) | GUCY1A1GUCY1B1ALDH1A1KMT2AKDM4E | |
| SCHEMBL12480878 | 0.80 | KMT2A (0.47) | GUCY1A1GUCY1B1ALDH1A1KMT2AKDM4E | |
| SCHEMBL12480365 | 0.80 | CFD (0.43) | GUCY1A1GUCY1B1ALDH1A1KMT2AKDM4E | |
| Lithium Ion SCHEMBL27927366 | 0.78 | GUCY1A1 (0.42) | GUCY1A1GUCY1B1ALDH1A1KMT2AKDM4E | |
| SCHEMBL20674150 | 0.74 | BAZ2B (0.46) | ALDH1A1KMT2AKDM4EMEN1MAPT | |
| SCHEMBL3897812 | 0.74 | KMT2A (0.49) | ALDH1A1KMT2AKDM4EMEN1MAPT | |
| SCHEMBL15596018 | 0.73 | KMT2A (0.44) | ALDH1A1KMT2AKDM4EMEN1MAPT | |
| SCHEMBL5354841 | 0.72 | KDM4E (0.56) | ALDH1A1KMT2AKDM4ECYP1A2CYP2C19 | |
| SCHEMBL4498121 | 0.71 | MAPT (0.63) | GUCY1A1GUCY1B1ALDH1A1KMT2AKDM4E | |
| Acetic Acid SCHEMBL27927368 | 0.71 | MAPK1 (0.43) | ALDH1A1KMT2AKDM4EMEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103402996-B | Indole compounds or analogues thereof useful for the treatment of age-related macular degeneration (AMD) | NOVARTIS AG | 2015-02-11 | — | — | CN | disclosed |
| CN-103402996-A | Indole compounds or analogues thereof useful for the treatment of age-related macular degeneration (AMD) | NOVARTIS AG | 2013-11-20 | — | — | CN | disclosed |