Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC18A3 | Q16572 | 4/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.38 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.38 |
| ▸ | GRIA4 | P48058 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.35 |
| ▸ | FABP7 | O15540 | 2/20 | 0.35 |
| ▸ | FABP3 | P05413 | 2/20 | 0.35 |
| ▸ | FABP5 | Q01469 | 2/20 | 0.35 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.35 |
| ▸ | SCN1A | P35498 | 1/20 | 0.35 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.35 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.35 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12208421 | 0.85 | MEN1 (0.42) | SLC18A3MEN1KMT2AGRIA4HPGD | |
| SCHEMBL19192739 | 0.81 | SLC18A3 (0.61) | SLC18A3MEN1KMT2AGRIA4SCN1A | |
| SCHEMBL15380659 | 0.76 | SLC18A3 (0.56) | SLC18A3MEN1KMT2AMAOAMAOB | |
| SCHEMBL10079800 | 0.76 | GRIA4 (0.38) | MEN1KMT2AGRIA4HPGDHRH3 | |
| SCHEMBL21399753 | 0.74 | SLC18A3 (0.54) | SLC18A3MEN1KMT2AFABP7FABP3 | |
| Acrolein SCHEMBL6271087 | 0.73 | MEN1 (0.39) | SLC18A3MEN1KMT2AKCNQ3KCNQ2 | |
| Bicarbonate SCHEMBL7569185 | 0.73 | MEN1 (0.57) | SLC18A3MEN1KMT2AKCNQ3KCNQ2 | |
| SCHEMBL9145559 | 0.72 | SLC18A3 (0.50) | SLC18A3MEN1KMT2AHPGDKDM4E | |
| SCHEMBL4606959 | 0.71 | SLC18A3 (0.54) | SLC18A3MEN1KMT2AMAOAMAOB | |
| SCHEMBL15178310 | 0.71 | SLC18A3 (0.54) | SLC18A3MEN1KMT2AMAOAMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102015606-B | IRE-1 alpha inhibitors | MANNKIND CORP | 2015-02-04 | — | — | CN | disclosed |
| CN-103450077-A | IRE-1A inhibitors | MANNKIND CORP | 2013-12-18 | — | — | CN | disclosed |