SCHEMBL27946005

SCHEMBL27946005

OCCc1cccc2c1-c1ccc(Cl)cc1C2

nearest known ligand 0.40

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
HSP90AA1 P07900 1/20 0.40
METAP1 P53582 1/20 0.36
CA1 P00915 1/20 0.35
CA2 P00918 1/20 0.35
CA4 P22748 1/20 0.35
CA6 P23280 1/20 0.35
SLC1A3 P43003 1/20 0.34
SLC1A2 P43004 1/20 0.34
SLC1A1 P43005 1/20 0.34
DRD2 P14416 4/20 0.33
DRD4 P21917 4/20 0.33
CNR1 P21554 1/20 0.33
HRH1 P35367 1/20 0.33
CYP1A2 P05177 1/20 0.33
HTT P42858 1/20 0.33
DRD3 P35462 1/20 0.33
HSD17B3 P37058 1/20 0.32
ITGA1 P56199 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27642573 0.86 METAP1 (0.39) HSP90AA1METAP1CA1CA2CA4
SCHEMBL2313142 0.81 DRD2 (0.46) DRD2DRD4CYP1A2DRD3
SCHEMBL30241529 0.78 METAP1 (0.42) HSP90AA1METAP1CA1CA2CA4
SCHEMBL28863723 0.76 METAP1 (0.43) HSP90AA1METAP1CA1CA2CA4
SCHEMBL31497079 0.74 HSP90AA1 (0.46) HSP90AA1METAP1CA1CA2CA4
SCHEMBL24726895 0.73 HSP90AA1 (0.44) HSP90AA1METAP1CA1CA2CA4
SCHEMBL25929517 0.73 METAP1 (0.41) HSP90AA1METAP1CA1CA2CA4
SCHEMBL7189694 0.71 DRD3 (0.51) DRD2DRD4DRD3
SCHEMBL23862771 0.70 KCNH2 (0.41) HSP90AA1METAP1CA1CA2CA4
SCHEMBL28541741 0.70 HSP90AA1 (0.58) HSP90AA1METAP1CA1CA2CA4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-103408509-A Anti-malaria medical raw material benflumetol intermediate 2,7-dichlorofluorene-4-ethylene oxide synthesis process ZHANGJIAGANG WEISHENG BIOLOG PHARMACEUTICAL CO LTD 2013-11-27 CN claimed