SCHEMBL27946321

SCHEMBL27946321

Cc1ccc([Si](C)(C)C)c([SiH3])c1

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 4/20 0.36
CYP2A6 P11509 3/20 0.36
NQO2 P16083 1/20 0.32
TDP1 Q9NUW8 5/20 0.32
TP53 P04637 2/20 0.32
CYP3A4 P08684 1/20 0.32
THRB P10828 1/20 0.32
ALOX15 P16050 1/20 0.32
SMN1; SMN2 Q16637 1/20 0.32
TRPA1 O75762 1/20 0.32
ACHE P22303 3/20 0.32
PSMB8 P28062 1/20 0.31
KEAP1 Q14145 1/20 0.31
UHRF1 Q96T88 1/20 0.31
ALDH1A1 P00352 1/20 0.31
CCR1 P32246 1/20 0.31
CCR5 P51681 1/20 0.31
CCR8 P51685 1/20 0.31
KDM4E B2RXH2 1/20 0.31
MAPT P10636 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28806509 0.81 CYP1A2 (0.36) CYP1A2CYP2A6NQO2TDP1TP53
SCHEMBL28033237 0.75 TDP1 (0.44) CYP1A2CYP2A6NQO2TDP1TP53
SCHEMBL27946340 0.71 IDO1 (0.38) ALDH1A1IDO1
SCHEMBL29344114 0.71 LMNA (0.39) CYP1A2CYP2A6TDP1TP53THRB
SCHEMBL27946342 0.70
SCHEMBL9463221 0.70 TDP1 (0.44) CYP1A2CYP2A6NQO2TDP1TP53
SCHEMBL12816335 0.70 CYP1A2 (0.35) CYP1A2CYP2A6NQO2TDP1TP53
SCHEMBL12817487 0.70 CYP1A2 (0.35) CYP1A2CYP2A6NQO2TDP1TP53
SCHEMBL6424735 0.69
SCHEMBL27946312 0.68

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-103459406-B For the preparation of the method for transition metal complex, for the catalyzer of trimerization, for the preparation of the method for 1-hexene, for the preparation of the method (2) of the cyclopentadiene compound replaced SUMITOMO CHEMICAL CO.,LTD. (JP) 2016-03-16 CN disclosed
CN-103459406-A Method for producing the transition metal complex, catalyst for trimerization, method for producing 1-hexene, method for producing the substituted cyclopentadiene compound (2) SUMITOMO CHEMICAL CO 2013-12-18 CN disclosed