Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PAK4 | O96013 | 6/20 | 0.77 |
| ▸ | PAK1 | Q13153 | 2/20 | 0.69 |
| ▸ | PAK2 | Q13177 | 1/20 | 0.69 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.69 |
| ▸ | PAK6 | Q9NQU5 | 1/20 | 0.69 |
| ▸ | PAK5 | Q9P286 | 1/20 | 0.69 |
| ▸ | MAP3K14 | Q99558 | 11/20 | 0.42 |
| ▸ | PRKD1 | Q15139 | 2/20 | 0.41 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.37 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.37 |
| ▸ | CDC7 | O00311 | 2/20 | 0.35 |
| ▸ | CDK2 | P24941 | 2/20 | 0.35 |
| ▸ | PIKFYVE | Q9Y2I7 | 1/20 | 0.35 |
| ▸ | NCF1 | P14598 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11970925 | 0.87 | PAK4 (1.00) | PAK4PAK1PAK2PKN1PAK6 | |
| SCHEMBL11970750 | 0.85 | PAK4 (0.67) | PAK4PAK1PAK2PKN1PAK6 | |
| SCHEMBL12001656 | 0.83 | PAK4 (0.73) | PAK4PAK1PAK2PKN1PAK6 | |
| SCHEMBL12490008 | 0.83 | PAK4 (0.72) | PAK4PAK1PAK2PKN1PAK6 | |
| SCHEMBL11971116 | 0.82 | PAK4 (1.00) | PAK4PAK1PAK2PKN1PAK6 | |
| SCHEMBL11970826 | 0.80 | PAK4 (0.77) | PAK4PAK1PAK2PKN1PAK6 | |
| SCHEMBL11971027 | 0.80 | PAK4 (0.76) | PAK4PAK1PAK2PKN1PAK6 | |
| SCHEMBL12001859 | 0.78 | PAK4 (0.72) | PAK4PAK1PAK2PKN1PAK6 | |
| SCHEMBL12001808 | 0.77 | PAK4 (0.63) | PAK4PAK1PAK2PKN1PAK6 | |
| SCHEMBL12001432 | 0.76 | PAK4 (0.62) | PAK4PAK1PAK2PKN1PAK6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103476768-A | 6, 5-heterocyclic propargyl alcohol compounds and uses thereof | HOFFMANN LA ROCHE | 2013-12-25 | — | — | CN | disclosed |