Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PAK4 | O96013 | 6/20 | 0.63 |
| ▸ | PAK1 | Q13153 | 2/20 | 0.53 |
| ▸ | PAK2 | Q13177 | 1/20 | 0.53 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.53 |
| ▸ | PAK6 | Q9NQU5 | 1/20 | 0.53 |
| ▸ | PAK5 | Q9P286 | 1/20 | 0.53 |
| ▸ | MAP3K14 | Q99558 | 4/20 | 0.38 |
| ▸ | PRKD1 | Q15139 | 2/20 | 0.36 |
| ▸ | TTBK1 | Q5TCY1 | 5/20 | 0.32 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.32 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.32 |
| ▸ | LCK | P06239 | 1/20 | 0.31 |
| ▸ | LYN | P07948 | 1/20 | 0.31 |
| ▸ | HCK | P08631 | 1/20 | 0.31 |
| ▸ | SRC | P12931 | 1/20 | 0.31 |
| ▸ | KDR | P35968 | 1/20 | 0.31 |
| ▸ | BRAF | P15056 | 1/20 | 0.30 |
| ▸ | CDC7 | O00311 | 1/20 | 0.30 |
| ▸ | CDK2 | P24941 | 1/20 | 0.30 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12001656 | 0.86 | PAK4 (0.73) | PAK4PAK1PAK2PKN1PAK6 | |
| SCHEMBL11970826 | 0.85 | PAK4 (0.77) | PAK4PAK1PAK2PKN1PAK6 | |
| SCHEMBL12001432 | 0.83 | PAK4 (0.62) | PAK4PAK1PAK2PKN1PAK6 | |
| SCHEMBL11970925 | 0.77 | PAK4 (1.00) | PAK4PAK1PAK2PKN1PAK6 | |
| SCHEMBL11970750 | 0.77 | PAK4 (0.67) | PAK4PAK1PAK2PKN1PAK6 | |
| SCHEMBL27947246 | 0.77 | PAK4 (0.77) | PAK4PAK1PAK2PKN1PAK6 | |
| SCHEMBL11971027 | 0.72 | PAK4 (0.76) | PAK4PAK1PAK2PKN1PAK6 | |
| SCHEMBL12001859 | 0.72 | PAK4 (0.72) | PAK4PAK1PAK2PKN1PAK6 | |
| SCHEMBL12001783 | 0.71 | PAK4 (0.49) | PAK4PAK1PAK2PKN1PAK6 | |
| SCHEMBL12001582 | 0.71 | TTBK1 (0.41) | PAK4MAP3K14TTBK1CDC7CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120214762-A1 | 6,5-HETEROCYCLIC PROPARGYLIC ALCOHOL COMPOUNDS AND USES THEREFOR | GENENTECH, INC. (US) | 2012-08-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120214762-A1 | 6,5-HETEROCYCLIC PROPARGYLIC ALCOHOL COMPOUNDS AND USES THEREFOR | NFKB1, NFRKB, NFKBIA | PAK4 1856/4885PAK1 1017/4885PAK2 2155/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.