Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Guanine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 known ✓ | P27487 | 1/20 | 0.41 |
| ▸ | PNP | P00491 | 2/20 | 0.77 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | THRB | P10828 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | GDA | Q9Y2T3 | 1/20 | 0.46 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.43 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.43 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.43 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Guanine SCHEMBL27860604 | 0.93 | PNP (0.74) | PNPALDH1A1KDM4EMEN1MAPT | |
| Guanine SCHEMBL76056 | 0.92 | PNP (0.84) | PNPALDH1A1KDM4EMEN1MAPT | |
| Guanine SCHEMBL663746 | 0.92 | PNP (0.84) | PNPALDH1A1KDM4EMEN1MAPT | |
| Guanine SCHEMBL101895 | 0.92 | PNP (0.84) | PNPALDH1A1KDM4EMEN1MAPT | |
| Guanine SCHEMBL5372458 | 0.91 | PNP (0.81) | PNPALDH1A1KDM4EMEN1MAPT | |
| Guanine SCHEMBL28840730 | 0.90 | PNP (0.79) | PNPALDH1A1KDM4EMEN1MAPT | |
| Guanine SCHEMBL27448636 | 0.90 | PNP (0.79) | PNPALDH1A1KDM4EMEN1MAPT | |
| Guanine SCHEMBL28445236 | 0.88 | PNP (0.77) | PNPALDH1A1KDM4EMEN1MAPT | |
| Guanine SCHEMBL27619007 | 0.88 | PNP (0.77) | PNPALDH1A1KDM4EMEN1MAPT | |
| Guanine SCHEMBL7255284 | 0.88 | PNP (0.81) | PNPALDH1A1KDM4EMEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103463647-B | Response type nuclear magnetic resonance contrast agent based on naphthyridine amide as recognition site and preparation method thereof | UNIV DALIAN TECH | 2015-06-17 | — | — | CN | disclosed |
| CN-103463647-A | Response type nuclear magnetic resonance contrast agent based on naphthyridine amide as recognition site and preparation method thereof | UNIV DALIAN TECH | 2013-12-25 | — | — | CN | disclosed |