Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 known ✓ | P08172 | 1/20 | 0.35 |
| ▸ | CHRM1 known ✓ | P11229 | 1/20 | 0.35 |
| ▸ | CHRM3 known ✓ | P20309 | 1/20 | 0.35 |
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.35 |
| ▸ | SLC6A3 known ✓ | Q01959 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 2/20 | 0.38 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.37 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.35 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.35 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.35 |
| ▸ | HRH1 | P35367 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Iodide SCHEMBL27948715 | 0.96 | HTR2A (0.38) | HTR2ACYP11B1CYP11B2KDM4ELMNA | |
| Fluoride Ion SCHEMBL28807008 | 0.96 | HTR2A (0.38) | HTR2ACYP11B1CYP11B2KDM4ELMNA | |
| Bromide SCHEMBL27932934 | 0.96 | HTR2A (0.42) | HTR2ACYP11B1CYP11B2KDM4ELMNA | |
| Hydrochloric Acid SCHEMBL812426 | 0.85 | HTR2A (0.37) | HTR2ACYP11B1CYP11B2KDM4ELMNA | |
| Hydrochloric Acid SCHEMBL812264 | 0.82 | CYP3A4 (0.41) | HTR2ACYP11B1CYP11B2KDM4ELMNA | |
| Bromide SCHEMBL27933150 | 0.81 | HTR2A (0.40) | HTR2ACYP11B1CYP11B2KDM4ELMNA | |
| Iodide SCHEMBL27932952 | 0.81 | HTR2A (0.37) | HTR2ACYP11B1CYP11B2KDM4ELMNA | |
| Fluoride Ion SCHEMBL27948602 | 0.81 | HTR2A (0.37) | HTR2ACYP11B1CYP11B2KDM4ELMNA | |
| Hydrochloric Acid SCHEMBL27933128 | 0.80 | HTR2A (0.35) | HTR2AKDM4ELMNATP53CHRM2 | |
| Bromide SCHEMBL28807004 | 0.79 | HTR2A (0.45) | HTR2AKDM4ELMNATP53CHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111587256-B | Catalyst system and polymerization process using the same | 埃克森美孚化学专利公司 | 2023-05-19 | — | — | CN | claimed |
| CN-111587257-B | Mixed catalyst system with four metallocenes on a single support | 埃克森美孚化学专利公司 | 2023-02-10 | — | — | CN | claimed |
| CN-111108130-B | Has the advantages ofcontaining-CH2-SiMe3Hybrid catalysts of partially unbridged hafnocenes | 埃克森美孚化学专利公司 | 2022-06-28 | — | — | CN | claimed |
| CN-111587257-A | Mixed catalyst system with four metallocenes on a single support | 埃克森美孚化学专利公司 | 2020-08-25 | — | — | CN | claimed |
| CN-111108130-A | Has the advantages ofcontaining-CH2-SiMe3Hybrid catalysts of partially unbridged hafnocenes | 埃克森美孚化学专利公司 | 2020-05-05 | — | — | CN | claimed |
| CN-105980424-B | Making polyolefin products | 尤尼威蒂恩技术有限责任公司 | 2019-05-21 | — | — | CN | claimed |
| CN-105980424-A | Making polyolefin products | 尤尼威蒂恩技术有限责任公司 | 2016-09-28 | — | — | CN | claimed |
| CN-111587257-B | Mixed catalyst system with four metallocenes on a single support | 埃克森美孚化学专利公司 | 2023-02-10 | — | — | CN | disclosed |
| CN-111344316-B | Polyethylene compositions and articles made therefrom | 埃克森美孚化学专利公司 | 2023-02-03 | — | — | CN | disclosed |
| CN-111108130-B | Has the advantages ofcontaining-CH2-SiMe3Hybrid catalysts of partially unbridged hafnocenes | 埃克森美孚化学专利公司 | 2022-06-28 | — | — | CN | disclosed |
| CN-111587257-A | Mixed catalyst system with four metallocenes on a single support | 埃克森美孚化学专利公司 | 2020-08-25 | — | — | CN | disclosed |
| CN-111344316-A | Polyethylene compositions and articles made therefrom | 埃克森美孚化学专利公司 | 2020-06-26 | — | — | CN | disclosed |
| CN-111108130-A | Has the advantages ofcontaining-CH2-SiMe3Hybrid catalysts of partially unbridged hafnocenes | 埃克森美孚化学专利公司 | 2020-05-05 | — | — | CN | disclosed |
| CN-103509060-B | Metallocene compound, the carbon monoxide-olefin polymeric comprising metallocene compound and the olefine polymerizing process of use metallocene compound | 大林产业株式会社 | 2016-08-10 | — | — | CN | disclosed |
| CN-103509060-A | Metallocene compound, catalyst composite containing metallocene compound and olefin polymerization method using metallocene compound | DAELIM IND CO LTD | 2014-01-15 | — | — | CN | disclosed |