Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 11/20 | 0.68 |
| ▸ | RAB9A | P51151 | 2/20 | 0.67 |
| ▸ | POLB | P06746 | 1/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.59 |
| ▸ | MEN1 | O00255 | 4/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.59 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.59 |
| ▸ | USP2 | O75604 | 1/20 | 0.59 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.57 |
| ▸ | HPGD | P15428 | 2/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 3/20 | 0.57 |
| ▸ | IDE | P14735 | 1/20 | 0.57 |
| ▸ | MPI | P34949 | 1/20 | 0.57 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.57 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.57 |
| ▸ | GAA | P10253 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2284247 | 0.82 | KDM4E (0.69) | KDM4ERAB9APOLBKMT2AMEN1 | |
| SCHEMBL1058188 | 0.81 | KDM5A (0.68) | KDM4ERAB9APOLBKMT2AMEN1 | |
| SCHEMBL12857657 | 0.80 | KDM4E (1.00) | KDM4ERAB9APOLBKMT2AMEN1 | |
| SCHEMBL3985154 | 0.80 | KDM4E (0.74) | KDM4ERAB9AKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL6519951 | 0.80 | GSK3B (0.58) | KDM4EKMT2AMEN1ALDH1A1MAPT | |
| SCHEMBL1228041 | 0.79 | KDM4E (0.62) | KDM4ERAB9APOLBKMT2AMEN1 | |
| SCHEMBL30681958 | 0.78 | KDM4E (0.71) | KDM4ERAB9APOLBKMT2AMEN1 | |
| SCHEMBL1622313 | 0.78 | KDM4E (0.71) | KDM4ERAB9APOLBKMT2AMEN1 | |
| SCHEMBL7827583 | 0.78 | KDM5A (0.66) | KDM4ERAB9APOLBKMT2AMEN1 | |
| SCHEMBL15200787 | 0.78 | KMT2A (0.72) | KDM4ERAB9APOLBKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103508950-B | Containing 4-hydroxyl-2-quinolinones compound and the Synthesis and applications thereof of imine structure | NANKAI UNIVERSITY (CN) | 2016-04-20 | — | — | CN | disclosed |
| CN-103508950-A | 4-hydroxy-2-quinolinone compounds containing imine structure, and preparation and application thereof | UNIV NANKAI | 2014-01-15 | — | — | CN | disclosed |