Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 10/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.65 |
| ▸ | MAPT | P10636 | 4/20 | 0.65 |
| ▸ | GAA | P10253 | 1/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.64 |
| ▸ | MEN1 | O00255 | 5/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.64 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.64 |
| ▸ | IDE | P14735 | 1/20 | 0.62 |
| ▸ | MPI | P34949 | 1/20 | 0.62 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.62 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.62 |
| ▸ | POLB | P06746 | 2/20 | 0.60 |
| ▸ | RAB9A | P51151 | 3/20 | 0.59 |
| ▸ | NPC1 | O15118 | 2/20 | 0.58 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.58 |
| ▸ | DAO | P14920 | 1/20 | 0.57 |
| ▸ | DDO | Q99489 | 1/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3985154 | 0.84 | KDM4E (0.74) | KDM4EALDH1A1MAPTGAAKMT2A | |
| SCHEMBL29612172 | 0.83 | KDM4E (0.69) | KDM4EALDH1A1MAPTGAAKMT2A | |
| SCHEMBL19952775 | 0.83 | KDM4E (0.69) | KDM4EALDH1A1MAPTGAAKMT2A | |
| SCHEMBL1228041 | 0.83 | KDM4E (0.62) | KDM4EALDH1A1MAPTGAAKMT2A | |
| SCHEMBL1622313 | 0.82 | KDM4E (0.71) | KDM4EALDH1A1MAPTGAAKMT2A | |
| SCHEMBL30681958 | 0.82 | KDM4E (0.71) | KDM4EALDH1A1MAPTGAAKMT2A | |
| SCHEMBL7827583 | 0.82 | KDM5A (0.66) | KDM4EALDH1A1MAPTGAAKMT2A | |
| SCHEMBL15200787 | 0.82 | KMT2A (0.72) | KDM4EALDH1A1MAPTGAAKMT2A | |
| SCHEMBL27948877 | 0.82 | KDM4E (0.68) | KDM4EALDH1A1MAPTGAAKMT2A | |
| SCHEMBL13598046 | 0.82 | KMT2A (0.75) | KDM4EALDH1A1MAPTGAAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103508950-B | Containing 4-hydroxyl-2-quinolinones compound and the Synthesis and applications thereof of imine structure | NANKAI UNIVERSITY (CN) | 2016-04-20 | — | — | CN | disclosed |
| CN-103508950-A | 4-hydroxy-2-quinolinone compounds containing imine structure, and preparation and application thereof | UNIV NANKAI | 2014-01-15 | — | — | CN | disclosed |
| US-8524729-B2 | Cinnamoyl derivatives and use thereof | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2013-09-03 | — | — | US | disclosed |
| US-7989478-B2 | decreases expression of a Type I collage gene in a tissue to induce a reduction in accumulation of collagen and thereby improves tissue fibrosis | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2011-08-02 | — | — | US | disclosed |
| US-20070123521-A1 | Cinnamoyl derivatives and use thereof | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2007-05-31 | — | — | US | disclosed |
| US-20060211680-A1 | decreases expression of a Type I collage gene in a tissue to induce a reduction in accumulation of collagen and thereby improves tissue fibrosis | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2006-09-21 | — | — | US | disclosed |
| EP-1671950-A1 | CINNAMOYL DERIVATIVES AND USE THEREOF | Sumitomo Chemical Company, Limited (JP) | 2006-06-21 | — | — | EP | disclosed |
| EP-1671948-A1 | CINNAMOYL COMPOUND AND USE OF THE SAME | Sumitomo Chemical Company, Limited (JP) | 2006-06-21 | — | — | EP | disclosed |
| US-6861419-B2 | Substituted 1, 4-thiazepine and analogs as activators of caspases and inducers of apoptosis and the use thereof | CYTOVIA, INC. (US) | 2005-03-01 | — | — | US | disclosed |
| EP-1324993-A2 | SUBSTITUTED 1,4-THIAZEPINE AND ANALOGS AS ACTIVATORS OF CASPASES AND INDUCERS OF APOPTOSIS AND THE USE THEREOF | Cytovia, Inc. (US) | 2003-07-09 | — | — | EP | disclosed |
| US-20020010169-A1 | Substituted 1, 4-thiazepine and analogs as activators of caspases and inducers of apoptosis and the use thereof | CYTOVIA, INC. | 2002-01-24 | — | — | US | disclosed |
| WO-2001079187-A2 | SUBSTITUTED 1,4-THIAZEPINE AND ANALOGS AND THEIR USE AS ACTIVATORS OF CASPASES | CYTOVIA, INC. (US) | 2001-10-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060211680-A1 | decreases expression of a Type I collage gene in a tissue to induce a reduction in accumulation of collagen and thereby improves tissue fibrosis | COL2A1, COL1A1, COL14A1 | KDM4E 2443/4885ALDH1A1 576/4885MAPT 4848/4885 |
| US-20020010169-A1 | Substituted 1, 4-thiazepine and analogs as activators of caspases and inducers of apoptosis and the use thereof | CASP1, CASP14, CASP4 | KDM4E 1882/4885ALDH1A1 832/4885MAPT 3104/4885 |
| US-20070123521-A1 | Cinnamoyl derivatives and use thereof | CES2, EBP, CPT1A | KDM4E 3010/4885ALDH1A1 31/4885MAPT 2597/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.