Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITK | Q08881 | 1/20 | 0.36 |
| ▸ | PPARG | P37231 | 9/20 | 0.35 |
| ▸ | PPARA | Q07869 | 7/20 | 0.35 |
| ▸ | PPARD | Q03181 | 6/20 | 0.34 |
| ▸ | CCR2 | P41597 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | GCGR | P47871 | 1/20 | 0.31 |
| ▸ | CA12 | O43570 | 1/20 | 0.31 |
| ▸ | CA1 | P00915 | 1/20 | 0.31 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
| ▸ | CA9 | Q16790 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27950249 | 0.93 | PPARG (0.34) | ITKPPARGPPARAPPARDCCR2 | |
| SCHEMBL28810335 | 0.93 | PPARG (0.35) | ITKPPARGPPARAPPARDGCGR | |
| SCHEMBL27936037 | 0.87 | PPARG (0.34) | ITKPPARGPPARAPPARDTP53 | |
| SCHEMBL27936046 | 0.87 | PPARG (0.37) | ITKPPARGPPARAPPARDTP53 | |
| SCHEMBL28807369 | 0.87 | PPARG (0.34) | ITKPPARGPPARAPPARDTP53 | |
| SCHEMBL28809330 | 0.81 | PPARG (0.37) | ITKPPARGPPARAPPARDTP53 | |
| SCHEMBL12099652 | 0.81 | PPARG (0.45) | PPARGPPARAPPARDTP53MAPT | |
| SCHEMBL27950255 | 0.81 | PPARG (0.35) | ITKPPARGPPARAPPARD | |
| SCHEMBL28807362 | 0.80 | PPARG (0.39) | PPARGPPARAPPARDTP53MAPT | |
| SCHEMBL27950296 | 0.80 | PPARG (0.37) | ITKPPARGPPARAPPARDMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103554006-A | Use of indole derivatives as nurr-1 activators for the application thereof as a medicament for the treatment of parkinson's disease | FOURNIER LAB SA | 2014-02-05 | — | — | CN | disclosed |