Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | F2 | P00734 | 2/20 | 0.42 |
| ▸ | F12 | P00748 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | GMNN | O75496 | 1/20 | 0.41 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.41 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14358581 | 0.79 | KDM4E (0.48) | POLBF2F12LMNACYP1A2 | |
| SCHEMBL14358728 | 0.76 | SMN1; SMN2 (0.47) | RAB9ASMN1; SMN2NPC1TP53ADORA2A | |
| SCHEMBL27953970 | 0.75 | ADORA2A (0.44) | SMN1; SMN2ADORA2APOLBF2F12 | |
| SCHEMBL2216120 | 0.71 | TSHR (0.49) | RAB9ASMN1; SMN2NPC1TP53PKM | |
| SCHEMBL16183607 | 0.70 | SMN1; SMN2 (0.47) | RAB9ASMN1; SMN2NPC1TP53ADORA2A | |
| SCHEMBL16184099 | 0.69 | NPC1 (0.54) | RAB9ASMN1; SMN2NPC1TP53ADORA2A | |
| SCHEMBL14475056 | 0.69 | DHFR (0.56) | RAB9ANPC1ADORA2ACYP1A2MAPT | |
| SCHEMBL30843879 | 0.69 | CYP1A2 (0.62) | SMN1; SMN2TP53POLBLMNACYP1A2 | |
| SCHEMBL13272569 | 0.69 | CYP1A2 (0.62) | SMN1; SMN2TP53POLBLMNACYP1A2 | |
| SCHEMBL30804557 | 0.69 | CYP1A2 (0.62) | SMN1; SMN2TP53POLBLMNACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103703001-A | Quinazolines as therapeutic compounds and related methods of use | OTSUKA PHARMA CO LTD | 2014-04-02 | — | — | CN | disclosed |