Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 10/20 | 0.36 |
| ▸ | CYP11B1 | P15538 | 5/20 | 0.34 |
| ▸ | CYP11B2 | P19099 | 5/20 | 0.34 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.33 |
| ▸ | KDM1A | O60341 | 1/20 | 0.32 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.32 |
| ▸ | PGR | P06401 | 1/20 | 0.32 |
| ▸ | USP8 | P40818 | 1/20 | 0.31 |
| ▸ | USP7 | Q93009 | 1/20 | 0.31 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17687714 | 0.80 | TRPV4 (0.34) | ARCYP11B1CYP11B2TRPV4KCNJ1 | |
| SCHEMBL14723162 | 0.73 | AR (0.41) | ARCYP11B1CYP11B2KCNJ1 | |
| SCHEMBL2693449 | 0.72 | AR (0.47) | ARCYP11B1CYP11B2TRPV4USP8 | |
| SCHEMBL6364089 | 0.70 | TRPV4 (0.42) | ARCYP11B1CYP11B2TRPV4 | |
| SCHEMBL286934 | 0.70 | KCNJ1 (0.44) | KCNJ1 | |
| SCHEMBL27958739 | 0.69 | OPRL1 (0.43) | CYP11B1CYP11B2KCNJ1 | |
| SCHEMBL286664 | 0.69 | TRPV4 (0.47) | CYP11B1CYP11B2TRPV4KCNJ1 | |
| SCHEMBL16122042 | 0.69 | TRPV4 (0.41) | ARCYP11B1CYP11B2TRPV4 | |
| SCHEMBL24495511 | 0.67 | AR (0.45) | ARCYP11B1CYP11B2TRPV4 | |
| SCHEMBL31156144 | 0.67 | AR (0.40) | ARCYP11B1CYP11B2TRPV4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103874493-A | Inhibitors of the renal outer medullary potassium channel | MERCK SHARP & DOHME | 2014-06-18 | — | — | CN | disclosed |