Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 1/20 | 0.44 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.41 |
| ▸ | CNR2 | P34972 | 2/20 | 0.38 |
| ▸ | CNR1 | P21554 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31544901 | 0.90 | KDR (0.53) | KDRCNR2CNR1 | |
| SCHEMBL279412 | 0.89 | KDR (0.45) | KDRCNR2CNR1 | |
| SCHEMBL279645 | 0.87 | KDR (0.46) | KDRCNR2CNR1 | |
| SCHEMBL279753 | 0.85 | CNR2 (0.33) | KDROPRM1CNR2CNR1 | |
| SCHEMBL31545938 | 0.85 | CNR2 (0.41) | CNR2CNR1 | |
| SCHEMBL279874 | 0.83 | CNR2 (0.51) | KDRCNR2CNR1 | |
| SCHEMBL279804 | 0.80 | KDR (0.66) | KDRCNR2CNR1 | |
| SCHEMBL279382 | 0.80 | OPRM1 (0.55) | KDROPRM1CNR2CNR1 | |
| SCHEMBL11728967 | 0.80 | CNR2 (0.59) | KDRCNR2 | |
| SCHEMBL11634629 | 0.80 | CNR2 (0.59) | KDRCNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8133887-B2 | Oxaphenanthrene derivatives | MERCK PATENT GMBH (DE) | 2012-03-13 | — | — | US | disclosed |
| EP-1963299-B1 | OXAPHENANTHRENE DERIVATIVES | MERCK PATENT GMBH (DE) | 2012-01-18 | — | — | EP | disclosed |
| US-20080312224-A1 | Oxaphenanthrene Derivatives | MERCK PATENT GMBH (DE) | 2008-12-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080312224-A1 | Oxaphenanthrene Derivatives | CYP3A43, CYP1A1, CYP1A2 | KDR 1595/4885OPRM1 281/4885CNR2 1588/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.