Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 1/20 | 0.41 |
| ▸ | DHFR | P00374 | 2/20 | 0.40 |
| ▸ | GABRP | O00591 | 1/20 | 0.37 |
| ▸ | GABRD | O14764 | 1/20 | 0.37 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.37 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.37 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.37 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.37 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.37 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.37 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.37 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.37 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.37 |
| ▸ | GABRE | P78334 | 1/20 | 0.37 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.37 |
| ▸ | GABRG1 | Q8N1C3 | 1/20 | 0.37 |
| ▸ | GABRG3 | Q99928 | 1/20 | 0.37 |
| ▸ | GABRQ | Q9UN88 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20274839 | 0.77 | REN (0.41) | RENDHFRPDPK1HEXAHEXB | |
| SCHEMBL4541979 | 0.75 | REN (0.45) | RENDHFRGABRPGABRDGABRA1 | |
| SCHEMBL4542814 | 0.74 | TLR8 (0.43) | RENGABRPGABRDGABRA1GABRB1 | |
| SCHEMBL22031208 | 0.74 | TLR8 (0.50) | TLR8TLR7 | |
| SCHEMBL17223741 | 0.70 | PDPK1 (0.44) | RENDHFRPDPK1 | |
| SCHEMBL17097382 | 0.69 | DYRK1A (0.41) | KAT2B | |
| SCHEMBL18824019 | 0.68 | TLR8 (0.64) | TLR8TLR7 | |
| SCHEMBL24175507 | 0.68 | KDR (0.40) | RENSMN1; SMN2HRH3HRH2 | |
| SCHEMBL17097386 | 0.68 | PARP1 (0.58) | — | |
| SCHEMBL4872319 | 0.67 | DYRK1A (0.33) | RENDHFRPDPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103958510-A | Pyrrolopyrimidine compounds for the treatment of cancer | UNIV NORTH CAROLINA | 2014-07-30 | — | — | CN | disclosed |