Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.47 |
| ▸ | VCP | P55072 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 3/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5680676 | 0.92 | TSHR (0.53) | LMNAALDH1A1NPSR1VCPSMN1; SMN2 | |
| SCHEMBL852513 | 0.86 | GAA (0.50) | NPSR1VCPSMN1; SMN2GAANPC1 | |
| SCHEMBL6747784 | 0.78 | NPSR1 (0.46) | LMNAALDH1A1NPSR1VCPGAA | |
| SCHEMBL9679306 | 0.77 | ALDH1A1 (0.52) | LMNAALDH1A1NPSR1NPC1RAB9A | |
| SCHEMBL2295271 | 0.77 | SMN1; SMN2 (0.46) | LMNAALDH1A1NPSR1VCPSMN1; SMN2 | |
| SCHEMBL124863 | 0.76 | NPSR1 (0.55) | LMNAALDH1A1NPSR1VCPNPC1 | |
| SCHEMBL2123773 | 0.76 | NPSR1 (0.55) | NPSR1VCPSMN1; SMN2GAANPC1 | |
| SCHEMBL15842836 | 0.75 | ELANE (0.43) | HTTTSHRTDP1L3MBTL1FFAR1 | |
| SCHEMBL777600 | 0.75 | NPSR1 (0.53) | LMNAALDH1A1NPSR1VCPSMN1; SMN2 | |
| SCHEMBL9865487 | 0.75 | CYP3A4 (0.50) | LMNAALDH1A1NPSR1VCPSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104003995-A | Pyrone-[3, 4-b] indole derivative and synthetic method thereof | UNIV SHANGHAI JIAOTONG | 2014-08-27 | — | — | CN | claimed |
| CN-104003995-B | Pyranone also [3,4-b] indole derivatives and synthetic method thereof | 上海交通大学 | 2016-10-26 | — | — | CN | disclosed |
| CN-104003995-A | Pyrone-[3, 4-b] indole derivative and synthetic method thereof | UNIV SHANGHAI JIAOTONG | 2014-08-27 | — | — | CN | disclosed |