Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRK2 | P25098 | 4/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | PRCP | P42785 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.36 |
| ▸ | TP53 | P04637 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.36 |
| ▸ | TACR1 | P25103 | 2/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.36 |
| ▸ | MPO | P05164 | 1/20 | 0.36 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.36 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.36 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tert-Butyl Formate SCHEMBL27970142 | 1.00 | GRK2 (0.40) | GRK2MEN1KMT2APRCPCYP3A4 | |
| Tert-Butyl Formate SCHEMBL28740523 | 0.89 | TLR9 (0.35) | GRK2TDP1TLR9TLR8TLR7 | |
| Tert-Butyl Formate SCHEMBL28104258 | 0.89 | TLR9 (0.35) | GRK2TDP1TLR9TLR8TLR7 | |
| Tert-Butyl Formate SCHEMBL28104098 | 0.89 | TLR9 (0.35) | GRK2TDP1TLR9TLR8TLR7 | |
| Tert-Butyl Formate SCHEMBL28046398 | 0.88 | TACR1 (0.41) | TACR1SLC6A4SLC6A2HTR2AOPRM1 | |
| Tert-Butyl Formate SCHEMBL27487856 | 0.87 | MAPT (0.43) | TACR1 | |
| Tert-Butyl Formate SCHEMBL28103964 | 0.86 | FPR1 (0.44) | MEN1KMT2AALDH1A1SMN1; SMN2 | |
| Tert-Butyl Formate SCHEMBL28805985 | 0.85 | KDM1A (0.40) | GRK2MEN1KMT2APRCPCYP3A4 | |
| Tert-Butyl Formate SCHEMBL27970140 | 0.84 | GRK2 (0.47) | GRK2MEN1KMT2ACYP3A4TP53 | |
| Tert-Butyl Formate SCHEMBL27970139 | 0.84 | GRK2 (0.47) | GRK2MEN1KMT2ACYP3A4TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104024251-A | BENZENESULFONAMIDE COMPOUNDS AND THEIR USE AS THERAPEUTIC AGENTS | XENON PHARMACEUTICALS INC | 2014-09-03 | — | — | CN | disclosed |