Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | KDM1A | O60341 | 2/20 | 0.41 |
| ▸ | NAMPT | P43490 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 3/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | MB | P02144 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14673029 | 0.86 | KDM1A (0.36) | SMN1; SMN2KDM1ANPC1RAB9AMEN1 | |
| SCHEMBL14673217 | 0.84 | KDM1A (0.56) | SMN1; SMN2KDM1AMAPTNPC1RAB9A | |
| SCHEMBL27973992 | 0.83 | TSHR (0.38) | SMN1; SMN2KDM1AMAPTALDH1A1KDM4E | |
| SCHEMBL27970716 | 0.82 | KDM1A (0.37) | KDM1AHTTMAPTRAB9AALDH1A1 | |
| SCHEMBL2564602 | 0.82 | KDM1A (0.37) | KDM1AALDH1A1CYP3A4 | |
| SCHEMBL27706519 | 0.82 | TACR1 (0.42) | SMN1; SMN2KDM1A | |
| SCHEMBL28271460 | 0.82 | SLC6A4 (0.40) | — | |
| SCHEMBL27891314 | 0.82 | KDM1A (0.51) | SMN1; SMN2KDM1ANAMPTHTTALDH1A1 | |
| SCHEMBL14673009 | 0.78 | NPC1 (0.41) | SMN1; SMN2MAPTNPC1RAB9AMEN1 | |
| SCHEMBL31727845 | 0.76 | KDM1A (0.36) | KDM1AMAPTNPC1RAB9AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103857393-B | Cyclopropylamine is as LSD1 inhibitor | 葛兰素史密斯克莱知识产权（第2 号）有限公司 | 2016-08-17 | — | — | CN | disclosed |
| CN-103857393-A | Cyclopropylamines as LSD1 inhibitors | GLAXOSMITHKLINE LLC | 2014-06-11 | — | — | CN | disclosed |