Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPRF | P10586 | 1/20 | 0.51 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.51 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.51 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.51 |
| ▸ | PRMT3 | O60678 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 4/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | KDR | P35968 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28086787 | 0.87 | MAPT (0.55) | MAPTMEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL27980421 | 0.80 | POLB (0.50) | MAPTMEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL11936086 | 0.80 | KDR (0.48) | PTPN1PTPN11MEN1KMT2AKDM4E | |
| SCHEMBL24904477 | 0.80 | KDR (0.62) | PTPN1PTPN11MEN1KMT2AKDM4E | |
| SCHEMBL15850552 | 0.79 | ALDH1A1 (0.51) | PRMT3MAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL212553 | 0.79 | NPC1 (0.61) | MEN1KMT2AKDM4EALDH1A1KDR | |
| SCHEMBL393608 | 0.78 | ALDH1A1 (0.53) | MAPTMEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL11890646 | 0.78 | MAPT (0.60) | PTPN2PTPN1MAPTMEN1KMT2A | |
| SCHEMBL11942246 | 0.77 | KDR (0.43) | PTPN1PTPN11MAPTMEN1KMT2A | |
| Ammonia Solution, Strong SCHEMBL9639241 | 0.76 | ALDH1A1 (0.51) | MAPTMEN1KMT2AKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103992310-B | One group replaces benzo heterocyclic amine derivant and preparation method thereof and the related application as IMPDH inhibitor | 中国医学科学院医药生物技术研究所 | 2016-07-06 | — | — | CN | disclosed |
| CN-103992310-A | Group of substituted benzoheterocycle amine derivatives and preparation method and related application thereof as IMPDH (inosine monophosphate dehydrogenase) inhibitor | INST MEDICINAL BIOTECHNOLOGY | 2014-08-20 | — | — | CN | disclosed |