Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 12/20 | 0.52 |
| ▸ | EGFR | P00533 | 5/20 | 0.41 |
| ▸ | PRKDC | P78527 | 4/20 | 0.41 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | NPY1R | P25929 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | NPY2R | P49146 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27975446 | 0.88 | LRRK2 (0.67) | LRRK2 | |
| SCHEMBL28813534 | 0.85 | LRRK2 (0.70) | LRRK2 | |
| SCHEMBL14059810 | 0.84 | LRRK2 (0.65) | LRRK2EGFRPRKDC | |
| SCHEMBL14059811 | 0.84 | LRRK2 (0.65) | LRRK2EGFRPRKDC | |
| SCHEMBL17135925 | 0.84 | LRRK2 (0.65) | LRRK2EGFRPRKDC | |
| SCHEMBL28830335 | 0.83 | LRRK2 (0.70) | LRRK2 | |
| SCHEMBL28814172 | 0.82 | LRRK2 (0.53) | LRRK2 | |
| SCHEMBL14062231 | 0.82 | LRRK2 (0.77) | LRRK2 | |
| SCHEMBL14062230 | 0.82 | LRRK2 (0.77) | LRRK2 | |
| SCHEMBL28813306 | 0.82 | LRRK2 (0.74) | LRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103917525-A | Inhibitors of LRRK2 kinase activity | ELAN PHARM INC | 2014-07-09 | — | — | CN | claimed |
| CN-103917525-A | Inhibitors of LRRK2 kinase activity | ELAN PHARM INC | 2014-07-09 | — | — | CN | disclosed |