Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 20/20 | 0.74 |
| ▸ | CSF1R | P07333 | 1/20 | 0.53 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27975105 | 0.88 | LRRK2 (0.71) | LRRK2CSF1RPDGFRA | |
| SCHEMBL28814189 | 0.85 | LRRK2 (0.71) | LRRK2CSF1RPDGFRA | |
| SCHEMBL14059621 | 0.85 | LRRK2 (1.00) | LRRK2CSF1RPDGFRA | |
| SCHEMBL14059619 | 0.85 | LRRK2 (1.00) | LRRK2CSF1RPDGFRA | |
| SCHEMBL17135863 | 0.85 | LRRK2 (1.00) | LRRK2CSF1RPDGFRA | |
| SCHEMBL27975370 | 0.83 | LRRK2 (0.65) | LRRK2CSF1RPDGFRA | |
| SCHEMBL17135946 | 0.83 | LRRK2 (1.00) | LRRK2CSF1RPDGFRA | |
| SCHEMBL17135945 | 0.83 | LRRK2 (1.00) | LRRK2CSF1RPDGFRA | |
| SCHEMBL27975550 | 0.82 | LRRK2 (0.52) | LRRK2 | |
| SCHEMBL27975422 | 0.81 | LRRK2 (0.69) | LRRK2CSF1RPDGFRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103917525-A | Inhibitors of LRRK2 kinase activity | ELAN PHARM INC | 2014-07-09 | — | — | CN | claimed |
| CN-103917525-A | Inhibitors of LRRK2 kinase activity | ELAN PHARM INC | 2014-07-09 | — | — | CN | disclosed |