Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 2/20 | 0.47 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.43 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.43 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.42 |
| ▸ | HSP90AB1 | P08238 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | IDO1 | P14902 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20666239 | 0.85 | DYRK1A (0.48) | DYRK1APDGFRBPDGFRAHSP90AA1HSP90AB1 | |
| SCHEMBL27976001 | 0.82 | DYRK1A (0.46) | DYRK1APDGFRBPDGFRAHSP90AA1HSP90AB1 | |
| SCHEMBL27976000 | 0.82 | DYRK1A (0.46) | DYRK1APDGFRBPDGFRAHSP90AA1HSP90AB1 | |
| SCHEMBL28813576 | 0.79 | KDM4E (0.49) | NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL27976334 | 0.76 | MEN1 (0.44) | DYRK1AHSP90AA1HSP90AB1MEN1NPC1 | |
| SCHEMBL20675592 | 0.76 | IDO1 (0.53) | DYRK1AHSP90AA1HSP90AB1MEN1NPC1 | |
| SCHEMBL27976323 | 0.74 | PLK1 (0.44) | MEN1NPC1RAB9AKMT2A | |
| SCHEMBL25248278 | 0.73 | PDGFRB (0.51) | DYRK1APDGFRBPDGFRAMEN1NPC1 | |
| SCHEMBL1556194 | 0.73 | CYP1A2 (0.52) | DYRK1APDGFRBPDGFRAHSP90AA1HSP90AB1 | |
| SCHEMBL13301167 | 0.73 | PSMD14 (0.59) | DYRK1APDGFRBPDGFRAHSP90AA1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103980194-A | 6,8-disubstituted quinoline compound or pharmaceutically acceptable salt thereof, preparing method and application of same | ZHEJIANG ACADEMY MEDICAL SCI | 2014-08-13 | — | — | CN | disclosed |