SCHEMBL27977666

SCHEMBL27977666

C=CCC1C(=O)N(c2cnn(Cc3c(C)noc3C)c2)C(=O)N1Cc1cccc(C(=O)NC)c1

nearest known ligand 0.66

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
▸ TAS2R8 Q9NYW2 20/20 0.66
▸ TAS2R14 Q9NYV8 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27990122 0.93 TAS2R8 (0.70) TAS2R8TAS2R14
SCHEMBL27977928 0.86 TAS2R8 (0.69) TAS2R8TAS2R14
SCHEMBL1616758 0.81 TAS2R8 (0.87) TAS2R8TAS2R14
SCHEMBL1279197 0.80 TAS2R8 (1.00) TAS2R8TAS2R14
SCHEMBL1279189 0.80 TAS2R8 (1.00) TAS2R8TAS2R14
SCHEMBL1279130 0.80 TAS2R8 (1.00) TAS2R8TAS2R14
SCHEMBL1615866 0.75 TAS2R8 (0.85) TAS2R8TAS2R14
SCHEMBL1616744 0.75 TAS2R8 (0.85) TAS2R8TAS2R14
SCHEMBL1279186 0.75 TAS2R8 (1.00) TAS2R8TAS2R14
SCHEMBL1279395 0.75 TAS2R8 (1.00) TAS2R8TAS2R14

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-104130247-A Human T2R bitter taste receptors and the use thereof SENOMYX INC 2014-11-05 — — CN disclosed
CN-101828111-B Human T2R bitter taste receptor and uses thereof SENOMYX INC 2014-07-23 — — CN disclosed
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