Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CG | P48736 | 4/20 | 0.35 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.33 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.33 |
| ▸ | CTSD | P07339 | 1/20 | 0.33 |
| ▸ | BACE1 | P56817 | 1/20 | 0.33 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.33 |
| ▸ | PRKDC | P78527 | 1/20 | 0.32 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL612665 | 0.73 | PIK3CG (0.49) | PIK3CGHCRTR1HCRTR2CTSDBACE1 | |
| SCHEMBL610690 | 0.63 | PIK3CG (0.57) | PIK3CGHCRTR1HCRTR2CTSDBACE1 | |
| SCHEMBL611719 | 0.63 | PIK3CG (0.46) | PIK3CGHCRTR1HCRTR2CTSDBACE1 | |
| SCHEMBL611681 | 0.61 | PIK3CG (0.51) | PIK3CGHCRTR1HCRTR2CTSDBACE1 | |
| SCHEMBL612940 | 0.61 | SMN1; SMN2 (0.50) | CTSDBACE1BACE2 | |
| SCHEMBL613373 | 0.61 | PIK3CG (0.46) | PIK3CGHCRTR1HCRTR2CTSDBACE1 | |
| SCHEMBL610864 | 0.59 | SMN1; SMN2 (0.39) | PIK3CGCTSDBACE1BACE2PRKDC | |
| SCHEMBL18948309 | 0.59 | PIK3CG (0.34) | PIK3CGHCRTR1HCRTR2PRKDCHDAC4 | |
| SCHEMBL11918420 | 0.57 | AR (0.38) | HDAC4 | |
| SCHEMBL31182236 | 0.57 | METAP2 (0.50) | PIK3CGCTSDBACE1BACE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102762548-B | Isoindolinone inhibitors of phosphatidylinositol 3-kinase | VERTEX PHARMA | 2014-11-26 | — | — | CN | disclosed |