Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 15/20 | 0.41 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.40 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 3/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2672774 | 0.81 | PIK3CD (0.59) | PIK3CDPIK3CGPIK3CBPIK3CAHPGD | |
| SCHEMBL2673575 | 0.81 | PIK3CD (0.48) | PIK3CDPIK3CGPIK3CBPIK3CAHPGD | |
| SCHEMBL2674384 | 0.80 | PIK3CD (0.61) | PIK3CDPIK3CGPIK3CBPIK3CA | |
| SCHEMBL2675258 | 0.78 | PIK3CD (0.51) | PIK3CDPIK3CGPIK3CBPIK3CA | |
| SCHEMBL27979239 | 0.78 | PIK3CD (0.47) | PIK3CDPIK3CGPIK3CBPIK3CAHPGD | |
| SCHEMBL2673790 | 0.70 | PIK3CD (0.58) | PIK3CDPIK3CGPIK3CBPIK3CA | |
| SCHEMBL2674773 | 0.69 | PIK3CD (0.43) | PIK3CDPIK3CGPIK3CBPIK3CAHPGD | |
| SCHEMBL2674750 | 0.64 | PIK3CD (0.53) | PIK3CDPIK3CGPIK3CBPIK3CAMAPK1 | |
| SCHEMBL2270679 | 0.64 | PIK3CD (0.64) | PIK3CDPIK3CGPIK3CBPIK3CAHPGD | |
| SCHEMBL2673388 | 0.64 | PIK3CD (0.40) | PIK3CDPIK3CGPIK3CAHPGDKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102459272-B | Bicyclic pyrimidine PI3K inhibitor compounds selective for P110 delta, and methods of use | GENENTECH INC | 2014-08-06 | — | — | CN | disclosed |