Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 17/20 | 0.47 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.47 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.46 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2674384 | 0.85 | PIK3CD (0.61) | PIK3CDPIK3CGPIK3CBPIK3CA | |
| SCHEMBL2673575 | 0.85 | PIK3CD (0.48) | PIK3CDPIK3CGPIK3CBPIK3CAHPGD | |
| SCHEMBL2672774 | 0.84 | PIK3CD (0.59) | PIK3CDPIK3CGPIK3CBPIK3CAHPGD | |
| SCHEMBL2675258 | 0.84 | PIK3CD (0.51) | PIK3CDPIK3CGPIK3CBPIK3CA | |
| SCHEMBL27979004 | 0.78 | PIK3CD (0.41) | PIK3CDPIK3CGPIK3CBPIK3CAKDM4E | |
| SCHEMBL27979008 | 0.77 | PIK3CD (0.76) | PIK3CDPIK3CGPIK3CBPIK3CA | |
| SCHEMBL27979174 | 0.76 | PIK3CD (0.67) | PIK3CDPIK3CGPIK3CBPIK3CA | |
| SCHEMBL2673790 | 0.75 | PIK3CD (0.58) | PIK3CDPIK3CGPIK3CBPIK3CA | |
| SCHEMBL2674773 | 0.72 | PIK3CD (0.43) | PIK3CDPIK3CGPIK3CBPIK3CAKDM4E | |
| SCHEMBL2674750 | 0.71 | PIK3CD (0.53) | PIK3CDPIK3CGPIK3CBPIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102459272-B | Bicyclic pyrimidine PI3K inhibitor compounds selective for P110 delta, and methods of use | GENENTECH INC | 2014-08-06 | — | — | CN | disclosed |