Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.45 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
| ▸ | KIF11 | P52732 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | KCNN4 | O15554 | 3/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | ARG1 | P05089 | 1/20 | 0.41 |
| ▸ | ARG2 | P78540 | 1/20 | 0.41 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22190045 | 0.86 | SMN1; SMN2 (0.62) | SMN1; SMN2HIF1ACYP1A2CYP2C19CYP2C9 | |
| Methane SCHEMBL29238356 | 0.85 | SMN1; SMN2 (0.60) | SMN1; SMN2HIF1ACYP1A2CYP2C19CYP2C9 | |
| SCHEMBL8504875 | 0.80 | SMN1; SMN2 (0.50) | SMN1; SMN2HIF1ACYP1A2CYP2C19CYP2C9 | |
| SCHEMBL10885482 | 0.80 | MAPT (0.50) | SMN1; SMN2HIF1ACYP1A2CYP2C19MAPT | |
| SCHEMBL28850742 | 0.79 | AKR1B1 (0.47) | SMN1; SMN2HIF1AMAPTKMT2ATAAR1 | |
| SCHEMBL5307776 | 0.79 | KCNN4 (0.53) | SMN1; SMN2HIF1ACYP1A2CYP2C19CYP2C9 | |
| SCHEMBL15228216 | 0.78 | MAPT (0.48) | SMN1; SMN2HIF1ACYP1A2CYP2C19MAPT | |
| SCHEMBL6994278 | 0.78 | KMT2A (0.53) | HIF1ACYP1A2CYP2C19MAPTKMT2A | |
| SCHEMBL28193690 | 0.78 | CYP1A2 (0.55) | SMN1; SMN2HIF1ACYP1A2CYP2C19CYP2C9 | |
| SCHEMBL1492533 | 0.78 | SMN1; SMN2 (0.52) | SMN1; SMN2HIF1ACYP1A2CYP2C19CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104428301-A | NAMPT inhibitors | ABBVIE INC | 2015-03-18 | — | — | CN | claimed |
| CN-104428301-A | NAMPT inhibitors | ABBVIE INC | 2015-03-18 | — | — | CN | disclosed |