Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 4/20 | 0.64 |
| ▸ | PDGFRB | P09619 | 4/20 | 0.55 |
| ▸ | PDGFRA | P16234 | 4/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.55 |
| ▸ | HPGD | P15428 | 3/20 | 0.55 |
| ▸ | MAPT | P10636 | 2/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.55 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | CASP1 | P29466 | 1/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | MMP10 | P09238 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3968224 | 0.88 | SYK (0.51) | SYKPDGFRBPDGFRAKDM4EALDH1A1 | |
| SCHEMBL14659225 | 0.82 | SYK (0.49) | SYKPDGFRBPDGFRAKDM4EALDH1A1 | |
| SCHEMBL29933480 | 0.82 | SYK (0.49) | SYKPDGFRBPDGFRAKDM4EALDH1A1 | |
| SCHEMBL3971693 | 0.82 | SYK (0.49) | SYKPDGFRBPDGFRAKDM4EALDH1A1 | |
| SCHEMBL3969901 | 0.82 | SYK (0.64) | SYKPDGFRBPDGFRAKDM4EALDH1A1 | |
| SCHEMBL29505009 | 0.81 | SYK (0.62) | SYKPDGFRBPDGFRAKDM4EHPGD | |
| SCHEMBL22116920 | 0.81 | SYK (0.62) | SYKPDGFRBPDGFRAKDM4EHPGD | |
| SCHEMBL3971691 | 0.81 | SYK (0.48) | SYKPDGFRBPDGFRAKDM4EALDH1A1 | |
| SCHEMBL14658527 | 0.81 | SYK (0.62) | SYKPDGFRBPDGFRAKDM4EHPGD | |
| SCHEMBL3968718 | 0.79 | SYK (0.47) | SYKPDGFRBPDGFRAKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103958497-A | Uracil derivatives as AXL and c-MET kinase inhibitors | CEPHALON INC | 2014-07-30 | — | — | CN | disclosed |