Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 17/20 | 0.34 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.33 |
| ▸ | ELOVL1 | Q9BW60 | 1/20 | 0.32 |
| ▸ | CDK4 | P11802 | 1/20 | 0.30 |
| ▸ | CDK2 | P24941 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10010098 | 1.00 | MAPK1 (0.34) | MAPK1P2RX7ELOVL1CDK4CDK2 | |
| SCHEMBL27981741 | 0.88 | MAPK1 (0.33) | MAPK1P2RX7ELOVL1CDK4CDK2 | |
| SCHEMBL10009653 | 0.88 | MAPK1 (0.33) | MAPK1P2RX7ELOVL1CDK4CDK2 | |
| SCHEMBL10009095 | 0.88 | MAPK1 (0.33) | MAPK1P2RX7ELOVL1CDK4CDK2 | |
| SCHEMBL10009314 | 0.87 | MAPK1 (0.35) | MAPK1P2RX7 | |
| SCHEMBL10008635 | 0.87 | MAPK1 (0.35) | MAPK1P2RX7 | |
| SCHEMBL27982244 | 0.87 | MAPK1 (0.35) | MAPK1P2RX7 | |
| SCHEMBL10009796 | 0.85 | MAPK1 (0.34) | MAPK1P2RX7ELOVL1 | |
| SCHEMBL10009558 | 0.85 | MAPK1 (0.34) | MAPK1P2RX7ELOVL1 | |
| SCHEMBL27982242 | 0.85 | MAPK1 (0.34) | MAPK1P2RX7ELOVL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102574832-B | Substituted N-phenyl-1-(4-pyridinyl)-1H-pyrazol-3-amines | JANSSEN PHARMACEUTICA NV | 2014-09-24 | — | — | CN | disclosed |