Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 11/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | GSK3B | P49841 | 2/20 | 0.34 |
| ▸ | KCNJ6 | P48051 | 2/20 | 0.34 |
| ▸ | KCNJ5 | P48544 | 2/20 | 0.34 |
| ▸ | KCNJ3 | P48549 | 2/20 | 0.34 |
| ▸ | TDO2 | P48775 | 1/20 | 0.34 |
| ▸ | KCNN3 | Q9UGI6 | 1/20 | 0.32 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.32 |
| ▸ | DHFR | P00374 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10008635 | 1.00 | MAPK1 (0.35) | MAPK1KDM4EMAPTGSK3BKCNJ6 | |
| SCHEMBL10009314 | 1.00 | MAPK1 (0.35) | MAPK1KDM4EMAPTGSK3BKCNJ6 | |
| SCHEMBL10009558 | 0.91 | MAPK1 (0.34) | MAPK1P2RX7DHFR | |
| SCHEMBL27982242 | 0.91 | MAPK1 (0.34) | MAPK1P2RX7DHFR | |
| SCHEMBL10009796 | 0.91 | MAPK1 (0.34) | MAPK1P2RX7DHFR | |
| SCHEMBL27981746 | 0.87 | MAPK1 (0.34) | MAPK1P2RX7 | |
| SCHEMBL10010098 | 0.87 | MAPK1 (0.34) | MAPK1P2RX7 | |
| SCHEMBL1506198 | 0.86 | MAPK1 (0.38) | MAPK1KDM4EMAPTGSK3BKCNJ6 | |
| SCHEMBL10010256 | 0.86 | MAPK1 (0.41) | MAPK1KDM4EMAPTTDO2 | |
| SCHEMBL10009040 | 0.85 | P2RX7 (0.36) | MAPK1P2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102574832-B | Substituted N-phenyl-1-(4-pyridinyl)-1H-pyrazol-3-amines | JANSSEN PHARMACEUTICA NV | 2014-09-24 | — | — | CN | disclosed |