Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 2/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
| ▸ | GPR142 | Q7Z601 | 1/20 | 0.45 |
| ▸ | CDK2 | P24941 | 1/20 | 0.43 |
| ▸ | GSK3B | P49841 | 1/20 | 0.43 |
| ▸ | GALR2 | O43603 | 3/20 | 0.42 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.41 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.41 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.41 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.41 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.41 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.41 |
| ▸ | GALR1 | P47211 | 2/20 | 0.41 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.40 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27982315 | 0.85 | THRB (0.53) | MAPK1CYP2D6CYP2C9KCNH2GPR142 | |
| SCHEMBL1506242 | 0.84 | MAPK1 (0.46) | IGF1RMAPK1CYP2D6CYP2C9KCNH2 | |
| SCHEMBL1506469 | 0.82 | MAPK1 (0.46) | IGF1RMAPK1CYP2D6CYP2C9KCNH2 | |
| SCHEMBL1506248 | 0.82 | MAPK1 (0.44) | IGF1RMAPK1CYP2D6CYP2C9KCNH2 | |
| SCHEMBL27981727 | 0.81 | MAPK1 (0.45) | IGF1RMAPK1CYP2D6CYP2C9KCNH2 | |
| SCHEMBL10009879 | 0.81 | MAPK1 (0.45) | IGF1RMAPK1CYP2D6CYP2C9KCNH2 | |
| SCHEMBL10010866 | 0.80 | MAPK1 (0.46) | IGF1RMAPK1CYP2D6CYP2C9KCNH2 | |
| SCHEMBL10011182 | 0.80 | MAPK1 (0.41) | IGF1RMAPK1CYP2D6CYP2C9KCNH2 | |
| SCHEMBL1506231 | 0.78 | MAPK1 (0.45) | IGF1RMAPK1CYP2D6CYP2C9KCNH2 | |
| SCHEMBL10009161 | 0.78 | MAPK1 (0.50) | IGF1RMAPK1CYP2D6CYP2C9KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102574832-B | Substituted N-phenyl-1-(4-pyridinyl)-1H-pyrazol-3-amines | JANSSEN PHARMACEUTICA NV | 2014-09-24 | — | — | CN | disclosed |