Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.57 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.57 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.57 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.57 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.57 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.57 |
| ▸ | PLAU | P00749 | 2/20 | 0.56 |
| ▸ | HTR6 | P50406 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.47 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | MGLL | Q99685 | 1/20 | 0.44 |
| ▸ | CNR2 | P34972 | 1/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.42 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.42 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.42 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acrylamide SCHEMBL27983435 | 0.85 | PLAU (0.54) | HDAC8HDAC1HDAC2HDAC10HDAC6 | |
| SCHEMBL6087734 | 0.85 | HTR6 (0.70) | HDAC8HDAC1HDAC2HDAC10HDAC6 | |
| SCHEMBL31258083 | 0.85 | HTR6 (0.70) | HDAC8HDAC1HDAC2HDAC10HDAC6 | |
| SCHEMBL12472875 | 0.78 | PLAU (0.74) | HDAC8HDAC1HDAC2HDAC10HDAC6 | |
| SCHEMBL10874579 | 0.75 | HTR6 (0.64) | HDAC8HDAC1HDAC2HDAC10HDAC6 | |
| SCHEMBL6191822 | 0.74 | HDAC1 (0.63) | HDAC8HDAC1HDAC2HDAC10HDAC6 | |
| SCHEMBL1749348 | 0.74 | HDAC1 (0.72) | HDAC8HDAC1HDAC2HDAC10HDAC6 | |
| SCHEMBL12472826 | 0.73 | HDAC6 (1.00) | HDAC8HDAC1HDAC2HDAC10HDAC6 | |
| SCHEMBL14338710 | 0.73 | HTR6 (1.00) | HDAC8HDAC1HDAC2HDAC10HDAC6 | |
| SCHEMBL27422334 | 0.73 | HTR6 (0.70) | HDAC8HDAC1HDAC2HDAC10HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104130176-A | 1, 5-disubstituted indolone derivative and application thereof | UNIV TIANJIN SCIENCE & TECH | 2014-11-05 | — | — | CN | claimed |
| CN-104130176-A | 1, 5-disubstituted indolone derivative and application thereof | UNIV TIANJIN SCIENCE & TECH | 2014-11-05 | — | — | CN | disclosed |