Hydrocortisone

SCHEMBL27987447

CCCC(=O)O.CCCC(=O)OC1CC(=O)C=C2CC[C@@H]3[C@H]([C@@H](O)C[C@@]4(C)[C@H]3CC[C@]4(O)C(=O)CO)[C@]21C.C[C@]12CCC(=O)C=C1CC[C@@H]1[C@@H]2[C@@H](O)C[C@@]2(C)[C@H]1CC[C@]2(O)C(=O)CO

nearest known ligand 0.69

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

NR3C1

The experimentally established mechanism targets of Hydrocortisone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

	gene	UniProt	supporting neighbours	confidence
▸	NR3C1 known ✓	P04150	3/20	0.69

▸	HIF1A	Q16665	11/20	0.69

▸	NR3C2	P08235	6/20	0.69

▸	SMN1; SMN2	Q16637	3/20	0.69

▸	PGR	P06401	3/20	0.69

▸	KMT2A	Q03164	3/20	0.69

▸	CYP2C19	P33261	2/20	0.69

▸	HSD17B10	Q99714	2/20	0.69

▸	MAPT	P10636	2/20	0.69

▸	SERPINA6	P08185	2/20	0.69

▸	NFKB1	P19838	2/20	0.69

▸	CYP3A4	P08684	2/20	0.69

▸	SHBG	P04278	1/20	0.69

▸	POLB	P06746	1/20	0.60

▸	GAA	P10253	1/20	0.60

▸	LMNA	P02545	2/20	0.58

▸	AR	P10275	1/20	0.58

▸	CHRM1	P11229	1/20	0.58

▸	PMP22	Q01453	1/20	0.57

▸	TSHR	P16473	1/20	0.57

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
Hydrocortisone SCHEMBL21313285	0.97	HIF1A (0.72)	HIF1ANR3C2NR3C1SMN1; SMN2PGR
Butyric Acid SCHEMBL28140488	0.95	HIF1A (0.59)	HIF1ANR3C2NR3C1SMN1; SMN2PGR
Hydrocortisone SCHEMBL28070079	0.94	HIF1A (0.76)	HIF1ANR3C2NR3C1SMN1; SMN2PGR
Hydrocortisone SCHEMBL28134238	0.93	HIF1A (0.69)	HIF1ANR3C2NR3C1SMN1; SMN2PGR
Valeric Acid SCHEMBL28435896	0.92	HIF1A (0.57)	HIF1ANR3C2NR3C1SMN1; SMN2PGR
Propionic Acid SCHEMBL27929927	0.92	HIF1A (0.59)	HIF1ANR3C2NR3C1SMN1; SMN2PGR
SCHEMBL141828	0.92	HIF1A (0.62)	HIF1ANR3C2NR3C1SMN1; SMN2PGR
Butyric Acid SCHEMBL27495006	0.92	HIF1A (0.58)	HIF1ANR3C2NR3C1SMN1; SMN2PGR
Acetic Acid SCHEMBL27804797	0.92	HIF1A (0.60)	HIF1ANR3C2NR3C1SMN1; SMN2PGR
Water SCHEMBL27961624	0.91	HIF1A (0.61)	HIF1ANR3C2NR3C1SMN1; SMN2PGR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
CN-104224709-A	Oil-in-water emulsion-based medicinal preparation capable of efficiently releasing medicine	NINGBO RUNZENG MEDICAL SCIENCE & TECHNOLOGY CO LTD	2014-12-24	—	—	CN	disclosed