Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RY14 | Q15391 | 1/20 | 0.48 |
| ▸ | GUCY1B2 | O75343 | 12/20 | 0.42 |
| ▸ | GUCY1A2 | P33402 | 12/20 | 0.42 |
| ▸ | GUCY1A1 | Q02108 | 12/20 | 0.42 |
| ▸ | GUCY1B1 | Q02153 | 12/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | KDM4A | O75164 | 1/20 | 0.40 |
| ▸ | KDM5A | P29375 | 1/20 | 0.40 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.40 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.40 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.40 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.40 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.39 |
| ▸ | SLC16A3 | O15427 | 1/20 | 0.39 |
| ▸ | SLC16A1 | P53985 | 1/20 | 0.39 |
| ▸ | MCTS1 | Q9ULC4 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | MARS1 | P56192 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15069147 | 0.90 | GUCY1B2 (0.42) | P2RY14GUCY1B2GUCY1A2GUCY1A1GUCY1B1 | |
| SCHEMBL15068996 | 0.86 | GUCY1B2 (0.42) | GUCY1B2GUCY1A2GUCY1A1GUCY1B1MEN1 | |
| SCHEMBL15069268 | 0.86 | ALDH1A1 (0.42) | P2RY14GUCY1B2GUCY1A2GUCY1A1GUCY1B1 | |
| SCHEMBL17089004 | 0.81 | GUCY1B2 (0.59) | GUCY1B2GUCY1A2GUCY1A1GUCY1B1OPRK1 | |
| SCHEMBL15068684 | 0.79 | GUCY1B2 (0.48) | GUCY1B2GUCY1A2GUCY1A1GUCY1B1MEN1 | |
| SCHEMBL17611663 | 0.79 | GUCY1B2 (0.59) | P2RY14GUCY1B2GUCY1A2GUCY1A1GUCY1B1 | |
| SCHEMBL2921219 | 0.78 | P2RY14 (0.58) | P2RY14MEN1KMT2AKDM4AKDM5A | |
| SCHEMBL15087441 | 0.76 | GUCY1B2 (0.56) | GUCY1B2GUCY1A2GUCY1A1GUCY1B1OPRK1 | |
| SCHEMBL17611689 | 0.76 | P2RY14 (0.58) | P2RY14MEN1KMT2AKDM4AKDM5A | |
| SCHEMBL16796425 | 0.76 | P2RY14 (0.58) | P2RY14MEN1KMT2AKDM4AKDM5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104066731-A | 2-benzyl, 3- (pyrimidin-2-yl) substituted pyrazoles useful as SGC stimulators | IRONWOOD PHARMACEUTICALS INC | 2014-09-24 | — | — | CN | disclosed |