SCHEMBL27988239

SCHEMBL27988239

O=C(Cc1cc2ccccc2s1)OC(F)(F)F

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP2A6 P11509 3/20 0.50
AGXT P21549 1/20 0.46
ASIC3 Q9UHC3 1/20 0.46
LOXL2 Q9Y4K0 1/20 0.46
GLS O94925 2/20 0.43
ADRB2 P07550 1/20 0.43
BCL2L1 Q07817 1/20 0.41
KDM4C Q9H3R0 1/20 0.41
PREP P48147 1/20 0.40
HDAC3 O15379 1/20 0.40
HDAC4 P56524 1/20 0.40
HDAC1 Q13547 1/20 0.40
HDAC7 Q8WUI4 1/20 0.40
HDAC2 Q92769 1/20 0.40
HDAC10 Q969S8 1/20 0.40
HDAC11 Q96DB2 1/20 0.40
HDAC8 Q9BY41 1/20 0.40
HDAC6 Q9UBN7 1/20 0.40
HDAC9 Q9UKV0 1/20 0.40
HDAC5 Q9UQL6 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11221971 0.83 CYP2A6 (0.58) CYP2A6AGXTASIC3LOXL2GLS
SCHEMBL11221999 0.81 CYP2A6 (0.51) CYP2A6AGXTASIC3LOXL2GLS
SCHEMBL6964036 0.80 CYP2A6 (0.54) CYP2A6AGXTASIC3LOXL2GLS
SCHEMBL3048243 0.80 CYP2A6 (0.54) CYP2A6AGXTASIC3LOXL2GLS
SCHEMBL4231274 0.78 CYP2A6 (0.51) CYP2A6AGXTASIC3LOXL2GLS
SCHEMBL29534459 0.76 CYP2A6 (0.61) CYP2A6AGXTASIC3LOXL2GLS
SCHEMBL631264 0.76 CYP2A6 (0.61) CYP2A6AGXTASIC3LOXL2GLS
SCHEMBL1029348 0.74 CYP2A6 (0.59) CYP2A6AGXTASIC3LOXL2GLS
SCHEMBL11215245 0.74 CYP2A6 (0.59) CYP2A6AGXTASIC3LOXL2GLS
SCHEMBL31356469 0.74 CYP2A6 (0.59) CYP2A6AGXTASIC3LOXL2GLS

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-102083810-B Activator of peroxisome proliferator activated receptor NIPPON CHEMIPHAR CO.,LTD. (JP) 2014-10-29 CN disclosed