Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 14/20 | 0.48 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.44 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.44 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | TDO2 | P48775 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2550961 | 0.80 | ADORA2A (0.64) | ADORA2AADORA3ADORA2BADORA1 | |
| SCHEMBL20576697 | 0.79 | ADORA2A (0.53) | ADORA2AADORA3ADORA2BADORA1MAPT | |
| SCHEMBL2545871 | 0.78 | ADORA2A (0.64) | ADORA2AADORA3ADORA2BADORA1HTT | |
| SCHEMBL27992067 | 0.72 | ADORA2A (0.46) | ADORA2AADORA3ADORA2BADORA1HTT | |
| SCHEMBL27992037 | 0.71 | ADORA2A (0.60) | ADORA2AADORA3ADORA2BADORA1HTT | |
| SCHEMBL28815590 | 0.71 | LMNA (0.42) | ADORA2AADORA3ADORA2BADORA1HTT | |
| SCHEMBL30577986 | 0.71 | ADORA2A (0.44) | ADORA2AADORA1MAPTHSD17B10KDM4E | |
| SCHEMBL27992032 | 0.69 | ADORA2A (0.58) | ADORA2AADORA3ADORA2BADORA1KDM4E | |
| SCHEMBL28042494 | 0.69 | LMNA (0.42) | ADORA2AADORA3ADORA2BADORA1KDM4E | |
| SCHEMBL27991806 | 0.68 | ADORA2A (0.47) | ADORA2AADORA3ADORA2BADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102892761-B | 4 - aminopyrimidine derivatives and their as as adenosine a2a receptor antagonists | PALOBIOFARMA SL | 2015-02-04 | — | — | CN | claimed |
| CN-102892761-B | 4 - aminopyrimidine derivatives and their as as adenosine a2a receptor antagonists | PALOBIOFARMA SL | 2015-02-04 | — | — | CN | disclosed |