Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RPS6KB1 | P23443 | 19/20 | 0.66 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.49 |
| ▸ | AKT1 | P31749 | 9/20 | 0.45 |
| ▸ | AURKA | O14965 | 3/20 | 0.42 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16163311 | 0.79 | RPS6KB1 (1.00) | RPS6KB1AKT1AURKACHEK1KCNH2 | |
| SCHEMBL17547557 | 0.79 | RPS6KB1 (1.00) | RPS6KB1AKT1AURKACHEK1KCNH2 | |
| SCHEMBL27992801 | 0.67 | RPS6KB1 (0.65) | RPS6KB1AKT1 | |
| SCHEMBL666547 | 0.66 | RPS6KB1 (1.00) | RPS6KB1PDPK1AURKACHEK1KCNH2 | |
| SCHEMBL666548 | 0.66 | RPS6KB1 (1.00) | RPS6KB1PDPK1AURKACHEK1KCNH2 | |
| SCHEMBL666546 | 0.66 | RPS6KB1 (1.00) | RPS6KB1PDPK1AURKACHEK1KCNH2 | |
| SCHEMBL15054840 | 0.65 | RPS6KB1 (1.00) | RPS6KB1AKT1 | |
| SCHEMBL15073450 | 0.65 | RPS6KB1 (0.69) | RPS6KB1AKT1AURKA | |
| SCHEMBL15059813 | 0.63 | RPS6KB1 (1.00) | RPS6KB1AKT1 | |
| SCHEMBL27992577 | 0.63 | RPS6KB1 (0.77) | RPS6KB1AKT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104169258-A | Novel heterocyclic carboxamides as modulators of kinase activity | MERCK PATENT GMBH | 2014-11-26 | — | — | CN | disclosed |