Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.50 |
| ▸ | GLA | P06280 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.41 |
| ▸ | TRPC6 | Q9Y210 | 2/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.38 |
| ▸ | PARP1 | P09874 | 1/20 | 0.37 |
| ▸ | LCK | P06239 | 1/20 | 0.37 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | JAK1 | P23458 | 1/20 | 0.36 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14152280 | 0.94 | MAPK1 (0.57) | MAPK1KDM4EL3MBTL1GLAHTT | |
| SCHEMBL25953857 | 0.94 | MAPK1 (0.57) | MAPK1KDM4EL3MBTL1GLAHTT | |
| SCHEMBL23530224 | 0.88 | KDM4E (0.60) | MAPK1KDM4EL3MBTL1GLAHTT | |
| SCHEMBL31589442 | 0.88 | KDM4E (0.65) | MAPK1KDM4EL3MBTL1GLAHTT | |
| SCHEMBL24244946 | 0.86 | MAPK1 (0.49) | MAPK1KDM4EL3MBTL1GLAHTT | |
| SCHEMBL24107756 | 0.84 | MAPK1 (0.50) | MAPK1KDM4EL3MBTL1GLAHTT | |
| SCHEMBL30263333 | 0.84 | MAPK1 (0.50) | MAPK1KDM4EL3MBTL1GLAHTT | |
| SCHEMBL24244939 | 0.84 | MAPK1 (0.50) | MAPK1KDM4EL3MBTL1GLAHTT | |
| SCHEMBL24107474 | 0.84 | MAPK1 (0.50) | MAPK1KDM4EL3MBTL1GLAHTT | |
| SCHEMBL30263210 | 0.84 | MAPK1 (0.50) | MAPK1KDM4EL3MBTL1GLAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104311480-A | Picolinamide derivatives as kinase inhibitors | NOVARTIS AG | 2015-01-28 | — | — | CN | disclosed |
| CN-102203079-B | Pyridine carboxamide derivatives as kinase inhibitors | NOVARTIS AG | 2014-12-10 | — | — | CN | disclosed |