Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.60 |
| ▸ | MAP4K4 | O95819 | 3/20 | 0.58 |
| ▸ | ABL1 | P00519 | 4/20 | 0.57 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.56 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.56 |
| ▸ | MKNK1 | Q9BUB5 | 6/20 | 0.55 |
| ▸ | MKNK2 | Q9HBH9 | 6/20 | 0.55 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.54 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.54 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.51 |
| ▸ | AURKA | O14965 | 1/20 | 0.50 |
| ▸ | TPX2 | Q9ULW0 | 1/20 | 0.50 |
| ▸ | ALPL | P05186 | 1/20 | 0.48 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1758378 | 0.99 | SCN10A (0.61) | SCN10AMAP4K4ABL1CYP11B2CYP11B1 | |
| SCHEMBL27995027 | 0.88 | CYP11B2 (0.55) | SCN10AMAP4K4ABL1CYP11B2CYP11B1 | |
| SCHEMBL28129364 | 0.88 | CYP11B2 (0.55) | SCN10AMAP4K4ABL1CYP11B2CYP11B1 | |
| SCHEMBL27995243 | 0.88 | CYP11B2 (0.59) | SCN10AMAP4K4ABL1CYP11B2CYP11B1 | |
| SCHEMBL25003797 | 0.84 | SCN10A (0.67) | SCN10AABL1OPRM1KCNH2AURKA | |
| SCHEMBL640664 | 0.83 | SCN10A (0.67) | SCN10AMAP4K4ABL1CYP11B2CYP11B1 | |
| SCHEMBL9606759 | 0.81 | SCN10A (0.61) | SCN10AMAP4K4ABL1CYP11B2CYP11B1 | |
| SCHEMBL30602765 | 0.81 | SIRT2 (0.50) | SCN10AABL1CYP11B2CYP11B1MKNK1 | |
| SCHEMBL8297933 | 0.80 | ABL1 (0.56) | MAP4K4ABL1AURKATPX2 | |
| SCHEMBL641681 | 0.80 | SCN10A (0.63) | SCN10AABL1CYP11B2CYP11B1OPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104379574-B | For suppressing the heterocyclic carbamate derivatives of the activity of ABL1, ABL2 and BCR ABL1 | 诺华股份有限公司 | 2017-03-01 | — | — | CN | disclosed |
| CN-104334529-A | Compounds and compositions for inhibiting the activity of ABL1, ABL2, and BCR-ABL1 | NOVARTIS AG | 2015-02-04 | — | — | CN | disclosed |