Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK10 | P53779 | 2/20 | 0.56 |
| ▸ | AURKA | O14965 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 3/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.46 |
| ▸ | GFER | P55789 | 1/20 | 0.46 |
| ▸ | KDR | P35968 | 1/20 | 0.44 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.43 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | TNNI3K | Q59H18 | 1/20 | 0.42 |
| ▸ | CCNC | P24863 | 1/20 | 0.42 |
| ▸ | CDK8 | P49336 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ACP1 | P24666 | 1/20 | 0.40 |
| ▸ | MPL | P40238 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7341519 | 0.79 | MAPK10 (0.73) | MAPK10AURKAMEN1KMT2AMAPT | |
| SCHEMBL29796528 | 0.79 | MAPK10 (0.73) | MAPK10AURKAMEN1KMT2AMAPT | |
| SCHEMBL27564107 | 0.79 | JAK2 (0.46) | MAPK10AURKAMEN1KMT2AGFER | |
| SCHEMBL7677416 | 0.79 | MAPK10 (0.56) | MAPK10MEN1KMT2AMAPTGFER | |
| SCHEMBL4391902 | 0.79 | MAPK10 (0.56) | MAPK10MEN1KMT2AGFERKDR | |
| SCHEMBL28669238 | 0.79 | MEN1 (0.46) | MAPK10MEN1KMT2AGFERKDR | |
| SCHEMBL28698325 | 0.77 | MEN1 (0.41) | MAPK10MEN1KMT2AGFERKDR | |
| SCHEMBL4630887 | 0.76 | GSK3A (0.53) | KDRMKNK1MKNK2HTT | |
| SCHEMBL28045808 | 0.75 | MAPK10 (0.60) | MAPK10AURKAMEN1KMT2AMAPT | |
| SCHEMBL29501509 | 0.75 | EGFR (0.61) | MAPK10AURKAMEN1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102659689-B | 4-substituted-2-butoxy-5-fluoropyrimidine compounds, and preparation method and application thereof | UNIV ZHEJIANG TECHNOLOGY | 2014-12-17 | — | — | CN | claimed |
| CN-102659689-B | 4-substituted-2-butoxy-5-fluoropyrimidine compounds, and preparation method and application thereof | UNIV ZHEJIANG TECHNOLOGY | 2014-12-17 | — | — | CN | disclosed |